【摘要】 目的：探讨成纤维细胞生长因子21(FGF21)在妊娠期糖尿病(GDM)中的变化意义。方法：选取2021年2—5月于我院产科门诊初次确诊GDM孕妇82例，同期在产科门诊就诊正常孕妇94例。通过酶联免疫吸附法检测FGF21在GDM组和正常组血清中水平变化情况。分析GDM中糖脂代谢指标与FGF21关系，以及FGF21对GDM的诊断效果。结果：GDM组FGF21、低密度脂蛋白胆固醇(LDL-C)、同型半胱氨酸(Hcy)、糖化血红蛋白(HbA1c)水平高于对照组(P<0.05),FGF21对GDM诊断曲线下面积为0.743,FGF21联合Hcy诊断曲线下面积为0.871。结论：GDM患者血清中FGF21水平较健康孕妇升高，FGF21联合Hcy可用于GDM患者的早期诊断。更多还原

【Abstract】 Objective:To evaluate the effect and diagnostic value of FGF21 in Gestational diabetes mellitus(GDM).Methods:Pregnant women first diagnosed with GDM(n=82) who were recruited from February 2021 to May 2021 were selected as GDM group, and healthy pregnant women(n=94) were selected as control group.The serum levels of FGF21 in GDM group and normal group were detected by enzyme-linked immunosorbent assay. The differences of glucose metabolism and lipid metabolism in GDM group, and the diagnostic efficacy of FGF21 on GDM were analyzed.Results:The levels of FGF21,LDL-C,Hcy and HbA1 c in GDM group were higher than those in the control group(P< 0.05).The AUC of FGF21 index was 0.743,and the AUC of FGF21 combined with Hcy was 0.871.Conclusion:The serum level of FGF21 in GDM is higher than that in healthy pregnant women and FGF21 combined with Hcy can be used for early diagnosis of GDM patients.更多还原