【摘要】 目的：探讨Sestrin1、2在子宫内膜样腺癌中的表达及临床意义。方法：收集2011年1月—2016年12月我院经病理科确诊的子宫内膜样腺癌患者101例，同时收集增殖期子宫内膜30例、子宫内膜增生不伴非典型性40例以及子宫内膜增生伴非典型性40例的石蜡蜡块作为对照组。通过免疫组织化学法检测各子宫内膜组织中Sestrin1、2的表达情况，分析Sestrin1、2在子宫内膜样腺癌中的表达情况及其临床意义。结果：Sestrin1、2在子宫内膜样腺癌的表达明显低于增殖期子宫内膜(P<0.05),均与组织学分级显著相关(P<0.05),且双阴性表达病例的组织学分级明显高于双阳性表达(P<0.05);其中Sestrin1还与年龄相关(P<0.05),与浸润深度、淋巴结转移及FIGO分期无相关性(P>0.05),Sestrin2还与浸润深度相关(P<0.05),而与年龄、淋巴结转移及FIGO分期无相关性(P>0.05);Kaplan-Meier生存曲线显示，Sestrin1的表达情况与子宫内膜癌患者的生存率无相关性(P>0.05),Sestrin2的表达情况与子宫内膜癌患者的生存率有相关性(P=0.05)。二者在子宫内膜样腺癌中的表达呈正相关(r=15.132,P=0.000)。结论：Sestrin1、2在子宫内膜样腺癌中可能发挥了抑癌基因的作用，它们的低表达共同促进子宫内膜样腺癌的进展，检测Sestrin1、2的表达对判断子宫内膜样腺癌恶性程度、预后以及对子宫内膜样腺癌患者的病理诊断、临床治疗具有重要意义。更多还原

【Abstract】 Objective:To investigate the expression and clinical significance of Sestrin1 and 2 in endometrioid adenocarcinoma.Methods:A total of 101 cases of endometrioid adenocarcinoma diagnosed by pathology in our hospital from January 2011 to December 2016 were collected.Including 30 cases of proliferative endometrium tissue specimens, 40 cases of endometrial hyperplasia without atypia and 40 cases of atypical endometrial hyperplasia were used as control group. The expression of Sestrin1 and 2 in each endometrial tissue was detected by immunohistochemical method, and the expression of Sestrin1 and 2 in endometrioid adenocarcinoma and its clinical significance were analyzed.Results:The expression of Sestrin1 and 2 in endometrioid adenocarcinoma was significantly lower than that in proliferative endometrium(P<0.05),were significantly correlated with histological grade(P<0.05),and the histological grade of double negative expression was significantly higher than that of double positive expression(P<0.05).Sestrin1 was also correlated with age(P<0.05), but not with infiltration depth, lymph node metastasis and FIGO stage(P>0.05).Sestrin2 was correlated with infiltration depth(P<0.05),but not with age, lymph node metastasis and FIGO stage(P>0.05).Kaplan-Meier survival curve showed that the expression of Sestrin1 was not correlated with the survival rate of patients with endometrial cancer(P>0.05),while the expression of Sestrin2 was correlated with the survival rate of patients with endometrial cancer(P=0.05).There was a positive correlation between the two in endometrioid adenocarcinoma(r=15.132,P=0.000).Conclusion:Sestrin1 and 2 may play the role of tumor suppressor genes in endometrioid adenocarcinoma, and their low expression together promotes the progression of endometrioid adenocarcinoma.Detection of the expression of Sestrin1 and 2 is of great significance for judging the malignant degree and prognosis of endometrioid adenocarcinoma, as well as the pathological diagnosis and clinical treatment of patients with endometrioid adenocarcinoma.更多还原