【摘要】 目的 探讨基于静息态功能磁共振成像（Resting-State Functional Magnetic Resonance Imaging,rs-fMRI）的创伤性脑损伤（Traumatic Brain Injury,TBI）患者功能连接。方法 以14例TBI患者和12例健康对照（Healthy Controls,HC）为研究对象，对其rs-fMRI图像进行预处理，再通过独立成分分析（Independent Component Analysis,ICA）得到默认模式网络（Default Model Network,DMN）和执行控制网络（Executive Control Network,ECN），从两个脑网络中各选取4个脑区作为种子点进行功能连接分析，最后使用单样本t检验、双样本t检验以及配对t检验探索TBI被试脑损伤后3、6和12个月与HC组的DMN与ECN功能联通性差异及变化情况。结果 TBI患者恢复期三个时间点的功能连接均与HC组有显著差异，DMNECN双网络之间的功能联通性与单个网络内部相比变化更为突出。此外，左侧顶叶为一个关键节点，可能为TBI的后续治疗提供新方向。结论 TBI后患者大脑静息态脑网络DMN与ECN的功能连接存在显著异常，这种异常可能是导致患者存在长期认知障碍及其他后遗症的原因。更多还原

【Abstract】 Objective To explore the functional connection in patients with traumatic brain injury(TBI) based on resting-state functional magnetic resonance imaging(rs-fMRI). Methods The rs-fMRI images of 14 TBI patients and 12 healthy controls(HC)were preprocessed by independent component analysis(ICA) gets default model network(DMN) and executive control network(ECN), four brain regions were selected from each of the two brain networks as seed points for functional connection analysis.Finally, one-sample t-test, two-sample t-test and paired t-test were used to explore the differences and changes of functional connectivity between DMN and ECN at 3, 6 and 12 months after TBI injury compared with HC group. Results The functional connections of TBI patients at three time points during the recovery period were significantly different from that of HC group, and the functional connectivity between DMN and ECN network was more obvious than that within a single network. In addition, the left parietal lobe was a key node, which may provide a new direction for the subsequent treatment of TBI. Conclusion There are significant abnormalities in the functional connection between DMN and ECN in the resting brain network of patients after TBI,which may be the cause of long-term cognitive impairment and other sequelae.更多还原