【摘要】 目的 探究在水凝胶的降解行为下药物在眼后段的扩散过程，为评估局部药物浓度和优化可降解水凝胶的眼内释药性能提供研究基础。方法 通过有限元分析法建立可降解载药原位水凝胶在眼后段的药物传递模型。模型考虑水凝胶的降解作用、眼内压和视网膜色素上皮细胞主动吸收引起的对流作用，以及眼内吸收清除作用对药物扩散的影响，探究药物在眼后段中的浓度变化情况。结果 释药过程中，眼内药物主要向后部扩散，载药水凝胶的释药速度明显慢于溶液药物。结论 可降解水凝胶通过防止药物中心移动和限制凝胶内部药物扩散的方式延长药物在眼后段的停留时间，合理调整原位水凝胶注射位置和降解性能参数能有效提高其治疗效果。更多还原

【Abstract】 Objective To study the drug diffusion process in posterior eye under the biodegradation behavior of hydrogels, and to provide the research basis for evaluating local drug concentration and optimizing intraocular drug release performance of the biodegradable hydrogels. Methods Through finite element analysis, the drug delivery model of the biodegradable drug-loaded in-situ hydrogels in posterior eye was established. The effects of degradation of hydrogels, intraocular pressure and convection caused by active absorption of retinal pigment epithelial cells, as well as the effect of intraocular absorption and clearance on drug diffusion were considered to study the development of drug concentration in posterior eye. Results The intraocular drug diffused mainly to the posterior segment during drug release, and release rate of the drug-loaded hydrogels was significantly slower than that of the solution. Conclusions The biodegradable hydrogels prolong the residence time of drug in posterior eye by preventing movement of the drug center and limiting drug diffusion inside the hydrogels. Reasonable adjustment of the in-situ hydrogel injection position and degradation performance parameters can effectively improve its therapeutic effects.更多还原