【摘要】 为考察加热卷烟对环境空气质量的影响及其人群健康风险，采用真空辅助捕集装置捕集加热卷烟的气溶胶，结合气相色谱-氢火焰离子化检测器（GC-FID）对呼出气溶胶中主要成分（丙二醇、丙三醇、薄荷醇、烟碱、三醋酸甘油酯）进行定量分析；同时在吸烟机上模拟志愿者抽吸参数抽吸加热卷烟，测定吸入气溶胶中主要成分的释放量，并与呼出气溶胶进行比较研究。结果表明：(1)所建立的呼出气溶胶主要成分分析方法标准曲线线性关系良好（R~2≥0.999 9），检出限在0.10～0.41μg/mL之间，回收率在77.70%～120.00%之间，日内和日间精密度良好（日内RSD≤6.93%、日间RSD≤10.70%）。(2)加热卷烟呼出气溶胶中丙二醇和丙三醇的释放量较高，且丙三醇的释放量高于丙二醇；薄荷味加热卷烟呼出气溶胶中含有薄荷醇。(3)加热卷烟呼出气溶胶中主要成分的释放量显著低于吸入气溶胶，人体对丙二醇、丙三醇、薄荷醇、烟碱和三醋酸甘油酯的平均截留率分别为96.80%、96.20%、96.00%、99.60%和99.60%。更多还原

【Abstract】 To investigate the influences of heated tobacco products on environmental air quality and the human health risk, the exhaled aerosol after smoking heated tobacco products was collected with a vacuum assisted capture device. Five major chemical components(i.e. propylene glycol, glycerol,menthol, nicotine and glycerol triacetate)in the exhaled aerosol were quantitatively analyzed with a gas chromatography-flame ionization detector(GC-FID). Meantime, the heated tobacco product was also smoked by a smoking machine at the puffing parameters simulated volunteer smokers. The releases of the five chemical components in inhaled aerosol were determined and compared with those in the exhaled aerosol. The results showed that: 1)The developed method for exhaled aerosol of the heated tobacco product presented a linear calibration curve with correlation coefficient(R~2)≥0.999 9, and the limits of detection(LODs) between 0.10 and 0.41 μg/mL. The recoveries were in the range of 77.70%-120.00% with good intra-day(RSD≤6.93%)and inter-day precision(RSD≤10.70%). 2)The exhaled aerosol of the heated tobacco product contained higher releases of propylene glycol and glycerin, and the release of glycerin was higher than that of propylene glycol. There was menthol in the exhaled aerosol of the heated tobacco product with mint flavored tobacco rods. 3)The releases of the five chemical components in exhaled aerosol of the heated tobacco product were significantly lower than those in inhaled aerosol. The average retention efficiencies by the volunteers for propylene glycol,glycerin, menthol, nicotine and glycerol triacetate were 96.80%, 96.20%, 96.00%, 99.60% and 99.60%respectively.更多还原