【摘要】 目的 探讨血清异常凝血酶原（PIVKA-Ⅱ）、 γ谷氨酰转肽酶（γ-GT）与甲胎蛋白（AFP）联合检测诊断原发性肝癌（PHC）的价值。方法 选择100例PHC患者（PHC组）、同期100例良性肝病患者（良性肝病组）、 100名健康人（对照组），检测三组的PIVKA-Ⅱ、 γ-GT、 AFP水平，分析其诊断PHC的价值。结果 PHC组PIVKA-Ⅱ、 γ-GT、 AFP水平高于良性肝病组、对照组（P <0.05）；良性肝病组PIVKA-Ⅱ、 γ-GT、 AFP水平高于对照组（P <0.05）。PIVKA-Ⅱ、 γ-GT、 AFP及联合检测诊断PHC的AUC分别为0.830、 0.774、 0.860、 0.933，联合检测诊断PHC的AUC高于PIVKA-Ⅱ、 γ-GT、 AFP (P <0.05)。结论 PIVKA-Ⅱ、 γ-GT、 AFP在PHC患者中表达升高，三者联合检测有助于PHC的早期诊断。更多还原

【Abstract】 Objective To explore the value of combined detection of serum prothromb ininduced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ), γ glutamyl transpeptidase(γ-GT) and alpha fetoprotein(AFP) in the diagnosis of primary hepatocellular carcinoma(PHC).Methods 100 PHC patients(PHC group), 100 patients with benign liver disease(benign liver disease group) and 100 healthy people(control group) at the same period were selected. The PIVKA-Ⅱ, γ-GT and AFP levels among three groups were detected and the value in the diagnosis of PHC was analyzed. Results The PIVKA-Ⅱ, γ-GT and AFP levels of the PHC group were higher than those of the benign liver disease group and the control group(P <0.05). The PIVKA-Ⅱ, γ-GT and AFP levels of the benign liver disease group were higher than those of the control group(P <0.05). The AUC of PIVKA-Ⅱ, γ-GT, AFP and combined detection in the diagnosis of PHC were 0.830, 0.774,0.860 and 0.933, respectively. The AUC of combined detection in the diagnosis of PHC was higher than that of PIVKA-Ⅱ, γ-GT and AFP(P <0.05). Conclusions The expressions of PIVKA-Ⅱ, γ-GT and AFP are elevated in PHC patients, and the combined detection is helpful for the early diagnosis of PHC.更多还原