【摘要】 目的 探讨头孢拉定联合米诺环素软膏治疗牙周病的临床效果及安全性。方法 92例牙周病患者随机分为两组各46例，常规组给予头孢拉定治疗，干预组给予头孢拉定联合米诺环素软膏治疗，比较两组的牙周指标、临床疗效以及不良反应。结果 治疗6周后，干预组的PD、 PLI、 AL水平均显著低于常规组（P <0.05）。干预组的治疗总有效率为97.83%，显著高于常规组的84.78%(P <0.05)。治疗期间，两组的不良反应发生率比较，差异均无统计学意义（P>0.05）。结论 头孢拉定联合米诺环素软膏治疗牙周病效果显著，可改善患者的牙周临床症状，且不增加药物不良反应发生风险。更多还原

【Abstract】 Objective To explore the clinical effect and safety of cefradine combined with minocycline ointment in the treatment of periodontal disease. Methods 92 cases of patients with periodontal disease were randomly divided into two groups, with 46 cases in each group. The conventional group was treated with cefradine, and the intervention group was treated with cefradine combined with minocycline ointment. The periodontal indicators, clinical efficacy and adverse reactions were compared between the two groups. Results After 6 weeks of treatment, the levels of PD, PLI and AL in the intervention group were significantly lower than those in the conventional group(P <0.05).The total effective rate of treatment in the intervention group was 97.83%, significantly higher than 84.78% in the conventional group(P<0.05). No statistical difference was found between the two groups in the incidences of adverse reactions during treatment(P >0.05).Conclusions Cefradine combined with minocycline ointment in the treatment of periodontal disease has significant effect, which can improve the periodontal clinical symptoms of patients without increasing the risk of adverse drug reactions.更多还原