【摘要】 阿尔茨海默病号称“全球十大杀手”之一，因目前尚没有治愈的办法，其早期的病理变化备受关注。轴浆运输障碍已被报道为多种神经退行性疾病的早期病理特征，然而引起轴浆运输障碍的因素有很多，该文从驱动蛋白、微管及线粒体等3个方面引起的轴浆运输障碍与阿尔茨海默病的关系进行探讨，旨在深入研究神经元轴浆运输机制、为防治阿尔茨海默病提供新的思路。更多还原

【Abstract】 Alzheimer’s disease is known as one of the "top ten killers in the world".Due to lack of effective therapy at present,early pathological changes have captivated widespread attention.Axonal transport dysfunction has been reported as an early pathological feature of many neurodegenerative diseases.However,multiple factors can cause axonal transport dysfunction.In this article,the relationship between axonal transport dysfunction caused by kinesins,microtubules and mitochondria and Alzheimer’s disease was discussed,aiming to provide new ideas for the prevention and treatment of Alzheimer’s disease by in-depth study on axonal transport mechanism of neure.更多还原