【摘要】 前列腺素E₂（PGE₂）是前列腺素E的一种，属于类花生酸类物质，参与机体炎症反应与免疫调节。正常生理情况下，肠黏膜上皮处于不断自我更新的过程，其自我更新由肠隐窝底部的肠道干细胞（ISC）完成，ISC对维持肠黏膜完整性具有重要意义。随着PGE₂对成体干细胞（包括ISC等）作用的深入研究，发现PGE₂不仅参与炎症免疫反应，而且能通过激活Wnt等信号通路促进成体干细胞增殖，从而维持正常组织的新旧更替。该文主要综述PGE₂对肠黏膜损伤的修复作用及其对ISC功能的影响。更多还原

【Abstract】 Prostaglandin E₂（PGE₂）, as a member of prostaglandin E, belongs to eicosanoids. It participates in inflammatory reaction and immune regulation. Under normal physiological conditions, intestinal mucosa undergoes persistent self-renewal. This process is mediated by intestinal stem cells（ISC）, which reside in the base of intestinal crypts. ISC play a very important role in maintaining the integrity of intestinal mucosa. Along with in-depth study of the role of PGE₂ in adult stem cells（including ISC）, PGE₂ has been proven to not only participate in inflammatory reaction, but also promote the proliferation of adult stem cells by activating the Wnt signaling pathway, thereby properly maintaining normal intestinal tissue renewal. In this article, the role of PGE₂ in the repair of intestinal mucosal injury and the effect upon ISC were mainly reviewed.更多还原