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炎症细胞参与腹主动脉瘤的研究进展
Pathogenesis of Inflammatory Cell in Abdominal Aortic Aneurysm
【摘要】 腹主动脉瘤(AAA)发生和发展的主要机制包括炎症反应、平滑肌细胞凋亡以及细胞外基质降解。其中,平滑肌细胞凋亡又与炎症、氧化应激和内质网应激密切相关。越来越多的证据表明,炎症反应是AAA的主要始发因素,对AAA的发生和发展起着至关重要的作用。现就AAA与炎症细胞的最新研究进展予以综述。
【Abstract】 The main mechanisms of the occurrence and development of abdominal aortic aneurysm(AAA) include inflammation, apoptosis of smooth muscle cell and degradation of extracellular matrix.Among them, apoptosis of smooth muscle cell is closely related to inflammation, oxidative stress and endoplasmic reticulum stress.More and more evidence indicates that inflammatory reaction is the main originator of AAA and plays a crucial role in the occurrence and development of AAA.This article reviews the latest research progress of AAA and inflammatory cell.
【关键词】 腹主动脉瘤;
炎症反应;
免疫细胞;
平滑肌细胞;
内皮细胞;
【Key words】 Abdominal aortic aneurysm; Inflammatory reaction; Immunocyte; Smooth muscle cell; Endothelial cell;
【Key words】 Abdominal aortic aneurysm; Inflammatory reaction; Immunocyte; Smooth muscle cell; Endothelial cell;
【基金】 国家自然科学基金(81900400,81770273,82070310)
- 【文献出处】 心血管病学进展 ,Advances in Cardiovascular Diseases , 编辑部邮箱 ,2022年07期
- 【分类号】R543.16
- 【下载频次】258