【摘要】 目的 探讨急性脑梗死（acute cerebral infarction, ACI）患者应用重组人组织型纤溶酶原激活物（recombinant human tissue plasminogen activator, rt-PA）静脉溶栓治疗的临床治疗效果。方法 选取2019年8月—2020年8月威海口腔医院收治的急性脑梗死患者86例为研究对象，应用随机数表法分为常规组和观察组，每组43例。常规组采取临床常规治疗，观察组在常规组基础应用rt-PA溶栓治疗。对比两组患者临床疗效。结果治疗24 h和7 d后，观察组美国国立卫生院神经功能缺损评分（National Institutes of Health Neurological Impairment Score,NIHSS)均明显下降，常规组下降不明显，且观察组治疗后24 h与7 d后NIHSS优于常规组，差异有统计学意义（t=5.905、6.820,P<0.05）。治疗后，观察组患者Fugl-Meyer评测得分（Fugl-Meyer assessment method,FMA）与Barthel指数明显提高，观察组改善更为明显，差异有统计学意义（t=9.611,9.271,P<0.05）。观察组总有效率为74.41%，明显优于常规组，差异有统计学意义（χ~2=9.364,P<0.05）。观察组无死亡，生存率为100.00%，致残率为2.33%，明显优于常规组的79.07%、18.60%，差异有统计学意义(χ~2=7.942,4.468,P<0.05）。结论 ACI患者应用rt-PA静脉溶栓治疗，有利于促进神经功能恢复，有利于患者肢体功能恢复，提高日常生活能力，安全性高。更多还原

【Abstract】 Objective To discuss the clinical therapeutic effect of intravenous thrombolysis with recombinant human tissue plasminogen activator(rt-PA) in patients with acute cerebral infarction(ACI).Methods A total of 86 patients with acute cerebral infarction admitted to Weihai Stomatological Hospital from August 2019 to August 2020 were selectde as the research objects. The patients were divided into routine group and observation group by random number table method, 43 cases in each group. The routine group was given routine clinical treatment, and the observation group was given rt-PA thrombolytic therapy based on the routine group. The clinical efficacy of the two groups of patients was compared.Results After 24 h and 7 d of treatment, the National Institutes of Health Neurological Impairment Score(NIHSS) in the observation group decreased significantly, while the decrease in the routine group was not obvious, and the NIHSS of the observation group was better than that of the routine group after 24 h and 7 d after treatment, and the difference was statistically significant(t=5.905, 6.820, P<0.05). After treatment, the Fugl-Meyer Assessment Method(FMA) fest scores and Barthel index in the observation group were significantly improved, and the improvement in the observation group was more obvious, and the difference was statistically significant(t=9.611, 9.271,P<0.05). The total effective rate of the observation group was 74.41%, which was significantly better than that of the routine group, and the difference was statistically significant(χ~2=9.364, P<0.05). There was no death in the observation group, the survival rate was 100.00%, and the disability rate was 2.33%, which was significantly better than that of the routine group(79.07% and 18.60%), and the difference was statistically significant(χ~2=7.942, 4.468, P<0.05).Conclusion The application of rt-PA intravenous thrombolysis in patients with ACI is beneficial to promote the recovery of neurological function, the recovery of limb function, and the improvement of daily living ability, with high safety.更多还原