【摘要】 视网膜疾病是视力丧失的常见原因，近年来受到社会的广泛关注。视网膜细胞在受到氧化应激、衰老等内外环境的刺激时，经历一系列的病理改变从而发生功能障碍。在受损的视网膜细胞中，糖原合成酶激酶3β(GSK3β)的活性发生了改变，通过介导细胞凋亡、血管新生等多种效应参与调控视网膜疾病的发生发展，干预GSK3β调节通路治疗视网膜疾病具有潜在临床意义。本文就多种视网膜疾病中GSK3β的活性调节机制进行综述。更多还原

【Abstract】 Retinal disease is a common cause of vision loss and has received widespread attention in recent years. Retinal cells, when exposed to internal or external environmental stimuli such as oxidative stress and aging, will undergo a series of pathological changes and become dysfunctional. In the damaged retinal cells, glycogen synthase kinase 3 beta(GSK3β) is altered in activity and then regulates the development of retinal diseases by mediating apoptosis and angiogenesis. Regulation of GSK3β pathways has potential clinical significance in treating retinal diseases. This article reviews the regulation mechanisms of GSK3β activity in various retinal diseases.更多还原