【摘要】 干燥综合征(Sj9gren’s syndrome, SS)是一种慢性自身免疫性疾病，主要累及外分泌腺体，临床主要表现为口干、眼干，也可涉及全身多个系统。根据病因，SS可分为原发性和继发性。随着社会发展，SS的患病率呈逐年上升趋势，其确切病因和发病机制尚不明确。流行病学调查发现，原发性干燥综合征(Primary Sj9gren’s syndrome, pSS)的发病呈明显的性别和年龄差异，好发于女性，男女之比为1∶9～1∶10,好发年龄为30～60岁，而女性体内雌激素变化较男性大，提示人体雌激素水平的变化可能在pSS的发生和发展中起着重要作用。本文就雌激素在SS中的研究进展进行综述。更多还原

【Abstract】 Sj?gren’s Syndrome(SS) is a chronic autoimmune disease that mainly involves exocrine glands and is clinically characterized by dry mouth and eyes, as well as multiple systemic systems. SS can be classified as primary or secondary according to etiology. With the development of society, the prevalence of SS is increasing year by year, and its exact etiology and pathogenesis are still unknown. The prevalence of Primary Sj?gren’s syndrome(pSS) showed significant gender and age difference, with a male to female ratio of 1∶9 to 1∶10, and the onset age of pSS was 30 to 60 years old. The changes of estrogen in females were larger than that in males. It is suggested that the changes of estrogen level may play an important role in the occurrence and development of pSS. This paper summarizes the research progress of estrogen in SS.更多还原