【摘要】 目的 研究结直肠癌组织中Zeste同源物增强子2(EZH2)、NF-E1b表达与临床病理特征及预后的关系，以便促进结直肠癌的治疗和预后。方法 回顾性选取云南省肿瘤医院2012年1月至2015年8月收治的86例结直肠癌患者资料，采用免疫组织化学方法检测纳入标本中EZH2、NF-E1b的表达情况，分析和研究EZH2、NF-E1b表达在结直肠癌患者的表达情况、与结直肠癌临床病理特征的关系、与生存率的关系，同时采用生存COX回归分析影响结直肠癌患者预后生存的影响因素。结果 EZH2阳性、阴性表达为52例(60.5%)、34例(39.5%),NF-E1b阳性、阴性表达为53例(61.6%)、33例(38.4%)。低分化直肠癌患者EZH2阳性率显著高于中、高分化患者;淋巴转移患者EZH2阳性率显著高于淋巴未转移患者;年龄≥60岁直肠癌患者EZH2阳性率显著高于<60岁患者，差异具有统计学意义(P <0.05)。低分化直肠癌患者NF-E1b阳性率显著高于中、高分化患者;糖尿病患者NF-E1b阳性率显著高于非糖尿病患者，差异具有统计学意义(P <0.05)。NF-E1b阳性、阴性表达存活率为33.3%、66.7%,EZH2阳性、阴性表达存活率为20.0%、80.0%。影响结直肠癌患者存活状态危险影响因素是得到影响结直肠癌患者存活状态危险影响因素是NF-E1b阳性、EZH2阳性、低分化、有淋巴结转移。结论 EZH2表达情况与直结肠癌患者的分化程度明显相关，NF-E1b表达情况与结肠癌患者的分化程度、淋巴结转移相关，两者阳性表达与患者预后密切相关，临床应该加以重视。更多还原

【Abstract】 Objective To study the relationship between the expression of Zeste homolog enhancer 2( EZH2) and NF-E1b in colorectal cancer tissues with clinicopathological features and prognosis, so as to promote the treatment and prognosis of colorectal cancer. Methods The data of 86 patients with colorectal cancer admitted to our hospital( Yunnan Cancer Hospital/The Third Affiliated Hospital of Kunming Medical University) from January 2012 to August 2015 were retrospectively selected. The expression of NF-E1b, analyze and study the expression of EZH2 and NF-E1b in patients with colorectal cancer, the relationship with the clinicopathological characteristics of colorectal cancer, and the relationship with the survival rate, and use the survival COX regression analysis to analyze the effect of colorectal cancer Factors influencing the prognosis and survival of cancer patients. Results EZH2 was positive and negative in 52 cases( 60. 5%) and 34 cases( 39. 5%), and NF-E1b was positive and negative in 53 cases( 61. 6%) and33 cases( 38. 4%). The expression of EZH2 was significantly correlated with the degree of differentiation and diabetes of colorectal cancer patients, and the difference was statistically significant( P < 0. 05). The difference was not significant, and the difference was not statistically significant( P > 0. 05). The expression of NF-E1b was significantly correlated with the gender, degree of differentiation, lymph node metastasis and age of colon cancer patients, and the difference was statistically significant( P < 0. 05).There was no significant difference in diabetes mellitus( P > 0. 05). The survival rates of NF-E1b positive and negative expression were33. 3% and 66. 7%, and the survival rates of EZH2 positive and negative expression were 20. 0% and 80. 0%. The risk factors affecting the survival status of colorectal cancer patients were NF-E1b, EZH2, degree of differentiation, and lymph node metastasis.Conclusion The expression of EZH2 is significantly related to the degree of differentiation of patients with colorectal cancer, and the expression of NF-E1b is related to the degree of differentiation and lymph node metastasis of patients with colon cancer.更多还原