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柴胡的化学成分与药理作用研究进展

Chemical composition and pharmacological effects of Radix Bupleuri

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【作者】 李艳凤刘雅舒李艳生

【Author】 LI Yanfeng;LIU Yashu;LI Yansheng;School of Pharmacy, Heilongjiang University of Chinese Medicine, Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education;

【机构】 黑龙江中医药大学药学院教育部北药基础与应用研究重点实验室

【摘要】 目的 总结柴胡化学成分及药理作用的研究进展,为柴胡的质量控制及临床应用提供依据。方法 查阅有关柴胡化学成分及药理作用的文献,并进行归纳、总结。结果 柴胡中含有皂苷、挥发油、黄酮、多糖、炔类以及微量元素等成分,具有抗肿瘤、抗抑郁症、抗纤维化、降血脂、肝肺损伤保护等作用。结论 柴胡化学成分和药理作用的研究已取得一定进展,但对于成分-药效-毒性的关系还需更深入研究。

【Abstract】 Objective To summarize the research progress of chemical constituents and pharmacological action of Radix Bupleuri, and to provide basis for quality control and clinical application of Radix Bupleuri.Methods The literatures about chemical constituents and pharmacological action of Radix Bupleuri were reviewed and summarized.Results There are saponins, volatile oil, flavonoids, polysaccharides, alkynes and trace elements in Radix Bupleuri, which have the effects of anti-tumor, anti-depression, anti-fibrosis, lowering blood lipid, liver and lung injury protection.Conclusion Some progress has been made in the study of chemical constituents and pharmacological action of Radix Bupleuri, but the relationship between composition, pharmacodynamics and toxicity needs further study.

【关键词】 柴胡药理作用化学成分
【Key words】 Radix Bupleuripharmacological actionsaikosaponin
【基金】 国家重点研发计划项目(编号:2018YFC1707000,黑龙江省“头雁”团队)
  • 【文献出处】 西北药学杂志 ,Northwest Pharmaceutical Journal , 编辑部邮箱 ,2022年05期
  • 【分类号】R284;R285
  • 【被引频次】3
  • 【下载频次】2480
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