【摘要】 目的：探讨NGX6在乳腺癌中的表达及与乳腺影像报告数据系统(breast imaging reporting and data system, BI-RADS)超声特征及淋巴结转移的关系。方法：回顾性收集162例乳腺癌的超声声像图特征及临床资料，参照BI-RADS标准予以分类。免疫组织化学法检测乳腺癌组织中NGX6的表达，分析乳腺癌组织NGX6表达与BI-RADS超声特征及淋巴结转移的关系。结果：在162例乳腺癌中，92例(56.8%)NGX6阳性表达，70例(43.2%)NGX6阴性表达。NGX6阴性表达组的乳腺癌肿块血流丰富、乳腺癌BI-RADS高类别发生率及淋巴结转移发生率均高于NGX6阳性表达组。NGX6表达与肿瘤血流程度及BI-RADS超声分类呈负相关(分别P=0.043,P=0.020,P=0.005)。结论：NGX6作为一个抑癌基因，与乳腺癌BI-RADS超声分类及超声生物学特征相关，NGX6表达水平在一定程度上可反映乳腺癌生物学行为。更多还原

【Abstract】 Objective: To investigate the relationship of NGX6 expression in breast cancer with BI-RADS ultrasonic features and lymph node metastasis. Methods: Ultrasonic features and clinical data of 162 breast cancer cases were retrospectively collected and classified according to BI-RADS criteria. The expression of NGX6 in breast cancer tissues was detected by immunohistochemistry. The relationship of NGX6 expression in breast cancer with BI-RADS ultrasonic features and lymph node metastasis was analyzed. Results: There were 92(56.8%) NGX6 positive expressions and 70(43.2%) NGX6 negative expressions in 162 breast cancers. Compared with the NGX6 positive group, the NGX6 negative group showed a higher incidence of abundant blood flow, lymph node metastasis, and higher BI-RADS ultrasound category. NGX6 expression was negatively correlated with the degree of tumor blood flow and BI-RADS ultrasound classification(P=0.043, P=0.020, P=0.005, respectively). Conclusion: NGX6, as a tumor suppressor gene, is associated with BI-RADS ultrasound classification and ultrasound biological features of breast cancer, and NGX6 expression level can reflect the biological behavior of breast cancer to some extent.更多还原