【摘要】 目的 探究奥美拉唑碳酸氢钠胶囊与艾普拉唑对十二指肠溃疡的疗效。方法 接收介于2020年1月—2021年1月时间段的十二指肠溃疡患者共计100例，开展简单随机化方法的分组处理，试验组应用艾普拉唑治疗，对照组应用奥美拉唑碳酸氢钠胶囊治疗，对两组十二指肠溃疡患者治疗效果、症状消失时间、症状积分、不良反应发生率等的差异性进行分析。结果 经结果评定显示试验组治疗效果相比较于对照组更高，差异有统计学意义（P <0.05）；试验组嗳气消退时间、灼热感消退时间、泛酸消退时间、腹痛消退时间均短于对照组，差异有统计学意义（P <0.05）；两组治疗后嗳气、腹胀、烧心、泛酸、上腹部不适等症状积分均低于治疗前，差异有统计学意义（P <0.05）；试验组治疗后嗳气、腹胀、烧心、泛酸、上腹部不适等症状积分低于对照组，差异有统计学意义（P<0.05）；评定不良反应发生率，结果显示两组差异无统计学意义（P> 0.05）。结论 十二指肠溃疡患者接受奥美拉唑碳酸氢钠胶囊与艾普拉唑治疗，均可获得一定的效果，其中艾普拉唑的疗效更佳。更多还原

【Abstract】 Objective To investigate the effect of omeprazole sodium bicarbonate capsule and ilaprazole on duodenal ulcer. Methods A total of 100 patients with duodenal ulcer from January 2020 to January 2021were enrolled and randomly divided into two groups: the experimental group was treated with ilaprazole, the control group was treated with omeprazole sodium bicarbonate capsule. The difference of treatment effect, symptom disappearing time, symptom score and incidence of adverse reactions between two groups of patients with duodenal ulcer was analyzed. Results The treatment effect of the experimental group was higher than the control group, the difference was statistically significant(P < 0.05). The regressing time of belching, burning sensation, pantothenic acid and abdominal pain in experimental group was shorter than that in control group, the difference was statistically significant(P < 0.05). After treatment, scores of symptoms such as belching, abdominal distension, heartburn, pantothenic acid and upper abdominal discomfort in both groups were lower than before treatment,the difference was statistically significant(P < 0.05). After treatment,scores of symptoms such as belching, abdominal distension, heartburn,pantothenic acid and upper abdominal discomfort in experimental group were lower than those in control group, the difference was statistically significant(P < 0.05). The incidence of adverse reactions was assessed, and the results showed that there was no significant difference between the two groups(P > 0.05). Conclusion The treatment of omeprazole sodium bicarbonate capsule and ilaprazole in patients with duodenal ulcer can achieve certain effect, among which ilaprazole is more effective.更多还原