【摘要】 合成了2个有机锡羧酸酯化合物三（邻溴苄基）锡噻吩2-甲酸酯（1）和三（邻溴苄基）锡肉桂酸酯（2）。通过元素分析、红外光谱、核磁共振谱(¹H、¹³C和¹¹⁹Sn)、差热分析、X射线单晶衍射方法对1和2进行了结构表征,对其结构进行了量子化学从头计算。结果显示,化合物1和2均为单锡核结构,锡原子均为四配位的畸变四面体构型。体外抗癌活性研究表明化合物1和2对人乳腺癌细胞（MCF-7）、人非小细胞肺癌细胞（A549）和人大细胞肺癌细胞（H460）均显示出较强的抑制活性。更多还原

【Abstract】 Two organotin carboxylate compounds, tri(o-bromobenzyl)tin thiophene 2-carboxylate(1) and tri(o-bromobenzyl)tin cinnamate(2), have been synthesized. Compounds1 and2 were characterized by elemental analysis, IR spectroscopy, NMR(1 H,13 C, and119 Sn), thermogravimetric analysis, and single-crystal X-ray diffraction. The study on compounds1 and2 has been performed with quantum chemistry calculation and in vitro anticancer activity. The results showed that the tin atoms in compounds1 and2 have distorted tetrahedral geometry. Compounds1 and2 had strong inhibitory activities against human breast cancer cells(MCF-7), human non-small cell cancer cells(A549), and human lung cancer cell lines(H460). CCDC: 2109938,1; 2109939,2.更多还原