【摘要】 背景:近年我国溃疡性结肠炎(UC)的发病率逐渐上升，其发病机制与免疫系统功能紊乱有关。B7-H5是重要的免疫检查点分子，对于免疫功能的调节有重要意义。目的:探讨B7-H5在UC中的表达情况及其临床意义。方法:收集2010年1月—2020年12月苏州大学附属第一医院收治的65例UC组织标本，以同期5名健康人作为对照。采用免疫组化和免疫荧光法检测B7-H5表达情况，并分析其与UC患者临床病理特征的关系。结果:UC患者中B7-H5表达显著高于对照组(P<0.001)。UC患者B7-H5表达与ESR和CRP呈正相关(P<0.01),而与患者性别、年龄、病变范围、Mayo评分和UCEIS评分无关(P>0.05)。结论:UC患者中B7-H5表达显著增高，且与ESR和CRP相关，可作为反映UC患者炎症反应严重程度的新型标志物。更多还原

【Abstract】 Background: The incidence of ulcerative colitis(UC) has gradually increased in China in recent years. The pathogenesis of UC is related to the dysfunction of immune system. B7-H5 is an important immune checkpoint molecule and is significant for the regulation of immune function. Aims: To investigate the expression and clinical significance of B7-H5 in UC. Methods: A total of 65 UC tissue specimens were collected from Jan. 2010 to Dec. 2020 at the First Affiliated Hospital of Soochow University, and 5 healthy subjects were served as controls. Immunohistochemistry and immuno-fluorescence were used to detect the expression of B7-H5, and its relationship with clinicopathological characteristics of UC patients was analyzed. Results: Expression of B7-H5 was significantly increased in UC patients than in controls(P<0.001). B7-H5 expression in UC patients was positively correlated with ESR and CRP(P<0.01), but not related to gender, age, extent of lesion, Mayo score and UCEIS score(P>0.05). Conclusions: The expression of B7-H5 in UC patients is significantly increased and is correlated with ESR and CRP, and can be used as a new marker for reflecting the severity of inflammation in UC patients.更多还原