【摘要】 酒精相关性脂肪性肝病(alcohol related fatty liver disease, AFLD)和非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)是全球慢性肝病的重要病因。两种疾病的组织病理学改变和模式依赖于病理学家的判断，但临床诊断的脂肪肝很少有肝活检。虽然区别主要基于是否有大量饮酒史，遗憾的是NAFLD的人群中还包括众多的饮酒者，所以NAFLD被描述为与AFLD在形态学上相似的结果。在脂肪肝的鉴别诊断中，这些模糊的概念给临床医师带来了巨大的挑战。更多还原

【Abstract】 Alcohol related fatty liver disease(AFLD) and non-alcoholic fatty liver disease(NAFLD) are important causes of chronic liver disease worldwide. The histopathological charicteristics and patterns of both diseases are dependented on the judge of pathologists. However, liver biopsy is rarely used for the clinical diagnosis of fatty liver disease. The distinction between AFLD and NAFLD is essentially based on presence or absence of a history of significant alcohol intake. Unfortunately, there are many drinkers in the population of NAFLD. Thus, NAFLD is sometimes misdiagnosed as AFLD in morphology. These vague concepts bring great challenges to clinicians in the differential diagnosis of fatty liver disease.更多还原