【摘要】 目的：探索中药离子导入加速正畸牙移动的作用。方法：选取2020年1月至2021年8月于江西省人民医院进行正畸治疗的安氏Ⅱ类1分类女性患者30例，随机分成三组，各10例。所有患者拔除双侧上颌第一前磨牙，进行自身半口随机对照实验，选择单侧拔牙区颊侧进行丹参注射液离子导入（实验侧），对侧给予生理盐水处理（对照侧），随后远中移动尖牙，测量第1、2、3、4个月双侧尖牙远中移动距离。第一组患者仅在第1个月进行离子导入，第二组患者在第1、2个月进行离子导入，第三组患者在第1、2、3个月进行离子导入，同时在术前及术后4个月进行尖牙牙周临床指标测量。结果：第一组患者第1个月实验侧尖牙移动距离较对照侧增加0.33 mm，差异有统计学意义（P<0.05），第2、3、4个月两侧尖牙移动距离未见显著差异（P>0.05）；第二组患者第1、2个月实验侧尖牙移动距离较对照侧分别增加0.31 mm和0.35 mm，差异有统计学意义（P<0.05），第3、4个月两侧尖牙移动距离未见显著差异（P>0.05）；第三组患者第1、2、3个月实验侧尖牙移动距离较对照侧分别增加0.29 mm、0.34 mm和0.36 mm，差异有统计学意义（P<0.05），第4个月两侧尖牙移动距离未见显著差异（P>0.05）；与术前相比，术后4个月对照侧和实验侧尖牙牙周探诊深度（PD）、龈沟出血指数（SBI）变化对比，差异无统计学意义（P>0.05）。结论：丹参注射液离子导入可在短期内加速正畸牙移动，且不会增加牙周风险。更多还原

【Abstract】 Objective: To explore the effect of traditional chinese medicine iontophoresis on accelerating orthodontic tooth movement. Methods: Thirty female patients with Angle class Ⅱ classification 1 who were treated in Jiangxi Provincial People’s Hospital from January 2020 to August 2021 were selected, and were randomly divided into three groups with 10 people in each group. All patients were extracted bilateral maxillary first premolars, and a self-half randomized controlled trial was performed. Salvia injection iontophoresis was performed on the buccal side of the tooth extraction area(experimental side), and the contralateral side was treated with normal saline(control side), and then the canines were moved distally. The distances of bilateral canine distal movement were measured in the first, second, third and fourth month. The first group received iontophoresis only in the first month, the second group received iontophoresis in the first two months, and the third group received iontophoresis in the first three months. Periodontal clinical indexes of canines were measured before and 4 months after operation. Results: In the first month, the distances of bilateral canine distal movement of the experimental side in the first group increased 0.33 mm compared with that of the control side, with a statistically significant difference(P<0.05). There was no significant difference between the distances of bilateral canine distal movement of both sides from the second to the fourth month(P>0.05). In the first and second months, the distances of bilateral canine distal movement of the experimental side in the second group increased 0.31 mm and 0.35 mm respectively, compared with that of the control side, with a statistically significant difference(P <0.05). There was no significant difference between the distances of bilateral canine distal movement of both sides from the third and fourth month(P >0.05). In the first, second and third months, the distances of bilateral canine distal movement of the experimental side in the third group increased 0.29 mm, 0.34 mm and 0.36 mm respectively, compared with that of the control side, with a statistically significant difference(P<0.05). There was no significant difference between the distances of bilateral canine distal movement of both sides in the fourth month(P >0.05). There was no statistically significant difference in the changes of periodontal probing depth(PD) and sulcus bleeding index(SBI) between the control and experimental 4 months after surgery compared with preoperatively. Conclusion: Salvia miltiorrhiza injection iontophoresis can accelerate orthodontic tooth movement in the short term without increasing the periodontal risk.更多还原