【摘要】 胰腺癌是一种高度恶性肿瘤，近年来发病率呈逐年上升趋势。目前还没特别好的筛查、发现和治疗手段，因此迫切需要寻找新的有效安全的胰腺癌治疗方法。近年来，嵌合抗原受体T细胞免疫疗法（chimeric antigen receptor T-cell immunotherapy,CAR-T）在肿瘤方面取得了重大突破，作为目前有效的恶性肿瘤的治疗方式之一，CAR-T细胞治疗效果可持续数年，趋向于长期抗肿瘤记忆，可有效预防复发。该技术进步很快，新的进展几乎以月为单位出现，胰腺癌的根治可能会有实质改善。本文就CAR-T的基本组成、胰腺癌的热门靶点及其面临的主要挑战做出简单的概述，并总结了近期关于CAR-T研究的新进展以及解决问题的方向，为后续治疗胰腺癌提供研究思路。更多还原

【Abstract】 Pancreatic canceris a highly malignant tumor,and its incidence has been increasing year by year. There is currently a lack of particularly good screening,detection and treatment approach. Therefore,it′s urgent to develop and find new effective and safe treatments for pancreatic cancer. In recent years,chimeric antigen receptor T-cell immunotherapy(CAR-T)has made a major breakthrough in cancer treatment.As one of the effective treatment modalities for malignant tumors,the effect of CAR-T cell therapy can last for several years,tending to long-term anti-tumor memory,and can effectively prevent recurrence. The technology is advancing rapidly,with new advances occurring almost on a monthly basis,and eradication of pancreatic cancer may be substantially improved. This article provides a brief overview of the basic components of CAR-T,the popular targets for pancreatic cancer and the main challenges they face,and summarizes the recent new advances on CAR-T research and the direction of problem solving to provide research ideas for the subsequent treatment of pancreatic cancer.更多还原