【摘要】 目的：探讨腰部椎后肌群肌肉横截面积以及内脏肌肉面积与腰椎骨密度的相关性。方法：选取2018年7月至8月在芜湖市某医院的1 273名体检者为调查对象，利用定量CT测量L1和L2椎体平均骨密度、L1椎体中心层面椎后肌群横截面积以及内脏肌肉面积，采用多元线性回归分析法分析椎后肌群肌肉面积与骨密度的关系。结果：研究人群骨量异常率为39.98%(509/1 273)，骨量异常组身高、体重、椎后肌群横截面积、内脏肌肉面积较骨量正常组低，而年龄、空腹血糖、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇较骨量正常组高（P<0.05）。平滑曲线拟合结果显示：校正身高、体重、年龄、空腹血糖、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇后，骨量异常组骨密度的残差与椎后肌群横截面积的平滑曲线呈倒“U”型，椎后肌群横截面积≤200 cm2时，骨密度随椎后肌群横截面积升高而升高（t=2.605,P=0.010），而内脏肌肉面积≤210 cm2时，骨密度随内脏肌肉面积升高而升高（t=2.182,P=0.030）。结论：腰部椎后肌群肌肉面积与腰椎骨密度存在非线性关系，平滑曲线图形呈倒“U”型。更多还原

【Abstract】 Objective: To investigate the relationship of the cross-sectional area of posterior vertebral muscle group and visceral muscle area with bone mineral density(BMD) of lumbar vertebra in a health check-up population. Methods: The cross-sectional study was conducted on a health check-up population from a hospital of Wuhu City from Jul 1 to Aug 3,2018,with 1 273 individuals. BMD,the cross-sectional area of vertebral muscle group and visceral muscle area were measured using quantitative computed tomography(QCT). The serum biochemical parameters and posterior vertebral muscle area were compared between normal and abnormal BMD groups. Statistical analysis was performed using multiple linear regression analysis.Results:The rate of abnormal BMD was 39.98%(509/1 273),and the height,weight,cross-sectional area of posterior vertebral muscle and visceral muscle area were lower than those of the normal BMD group(P<0.05). While the age,glucose(GLU),total cholesterol(TC),high density lipoprotein(HDL) and low density lipoprotein(LDL) were higher than those of the normal BMD group(P<0.05). After adjusting for age,height,weight,TC,HDL,LDL and GLU,an inverted U-shape relationship was established between BMD residuals and cross-sectional area of posterior vertebral muscle. When the cross-sectional area of posterior vertebral muscle was≤200 cm2(t=2.605,P=0.010) or visceral muscle area≤210 cm2(t=2.182,P=0.030),the BMD increased with the increase of the area. Conclusions:There is nonlinear relationship between BMD and cross-sectional area of posterior vertebral muscle group,and the smooth curve graph is an inverted U-shape.更多还原