【摘要】 目的 探讨应用体外膜肺氧合(extracorporeal membrane oxygenation, ECMO)在救治高危肺栓塞患者的临床效果。方法 回顾性分析河南省人民医院重症医学科2015年1月至2022年12月应用ECMO救治高危PE患者的临床数据。结果 观察期间共10例患者因高危肺栓塞启动ECMO,7例为女性，平均年龄为65±0.57岁。6例患者在ECMO上机前通过超声心动图和/或肺动脉血管造影确诊为肺栓塞。5例患者接受了导管介入血栓抽吸治疗，3例患者接受ECMO联合持续抗凝治疗，2例患者接受重组人尿激酶原溶栓治疗。ECMO持续时间平均为93.59±62.05h, 8例患者成功撤离ECMO,30d生存率为70%。结论 高危肺栓塞患者应用ECMO可以提供血流动力学支持，ECMO联合其他再灌注治疗可能比单独应用ECMO更加具有生存优势。更多还原

【Abstract】 Objective To investigate the clinical effect of Extracorporeal Membrane Oxygenation(ECMO)in the treatment of high risk pulmonary embolism.Methods The clinical data of patients with high-risk PE treated with ECMO were retrospectively analyzed in the Department of Critical Care Medicine of Henan Provincial People’s Hospital from January,2015 to December, 2022.Results During the study period, 10 patients were initiated ECMO due to high-risk PE. Seven patients were female, with an average age of 65±0.57 years.Six patients were diagnosed with PE by echocardiography and/or pulmonary angiography(CTA) before ECMO. Five patients received catheter interventional thrombus aspiration, 3 patients received ECMO combined with continuous anticoagulation, and 2 patients received recombinant human prourokinase thrombolytic therapy. The mean duration of ECMO was 93.59±62.05 hours. Eight patients were successfully weaned from ECMO, and the 30-day survival rate was 70%.Conclusions ECMO can provide hemodynamic support for high-risk PE patients. ECMO combined with other reperfusion therapies may have a survival advantage over ECMO alone.更多还原