【摘要】 目的 探讨ADP核糖基化样因子2(ARL2)、B细胞异位基因2(BTG2)蛋白在非小细胞肺癌组织中表达水平及与其临床预后的关系。方法 选取126例非小细胞肺癌患者作为研究对象，应用免疫组化法测定癌组织及癌旁组织中ARL2、BTG2蛋白表达。采用χ~2检验分析ARL2、BTG2蛋白表达与其临床病理特征的关系，多因素Cox回归分析非小细胞肺癌患者的预后相关因素。结果 非小细胞肺癌组ARL2蛋白阳性率高于癌旁组(66.7%vs 25.4%),BTG2蛋白阳性率低于癌旁组(20.6%vs 71.4%)(P<0.05)。ARL2、BTG2蛋白表达与年龄、性别无关(P>0.05);与肿瘤最大直径、浸润深度、TNM分期、淋巴结转移、病理分级、复发相关，且肿瘤最大直径至少5 cm、浸润深度越深、TNM分期越高、病理级别越高、出现淋巴结转移、有复发的非小细胞肺癌患者ARL2阳性表达率更高，BTG2阳性表达率更低(P<0.05)。ARL2阴性、BTG2阳性的非小细胞肺癌患者5年内生存率明显上升(P<0.05)。肿瘤最大直径至少3cm、TNM分期为Ⅲ～Ⅳ期、浸润深度至少为1 cm、出现淋巴血管浸润、有复发、高病理级别、ARL2阳性、BTG2阴性的非小细胞肺癌患者5年内生存率下降明显(P<0.05)。TNM分期为Ⅲ～Ⅳ期、高病理级别、ARL2阳性、BTG2阴性是影响非小细胞肺癌患者预后的独立危险因素(P<0.05)。结论 非小细胞肺癌组织中ARL2蛋白表达升高，BTG2蛋白表达降低；ARL2阳性蛋白、BTG2阴性表达是影响非小细胞肺癌患者预后的独立危险因素。更多还原

【Abstract】 Objective To investigate the expression levels of ARL2 and BTG2 proteins in cancer tissues of patients with non-small cell lung cancer and their clinical prognostic significance.Methods A total of 126 patients with non-small cell lung cancer were selected as the research objects, and the expression of ARL2 and BTG2 proteins in cancer tissues and adjacent tissues was determined by immunohistochemistry.χ~2 test was used to analyze the relationship between ARL2,BTG2 protein expression and the clinical pathological characteristics of patients, and multivariate Cox regression analysis was used to investigated the prognostic factors of patients with non-small cell lung cancer.Results The positive rate of ARL2 protein in the non-small cell lung cancer group was higher than adjacent group(66.7% vs 25.4%),and the positive rate of BTG2 protein was lower than adjacent group(20.6% vs 71.4%)(P<0.05).The expression of ARL2 and BTG2 protein were not related with age and gender(P>0.05).The expression of ARL2 and BTG2 were related with the maximum diameter of the tumor, TNM stage, depth of invasion, pathological grade, lymph node metastasis, recurrence, and the maximum diameter of the tumor≥3 cm, the higher the TNM stage, the deeper the infiltration depth, the higher the pathological grade, and the recurrence of non-small cell lung cancer, the higher the positive expression rate of ARL2 in patients with lymph node metastasis, the lower the positive expression rate of BTG2(P<0.05).The 5-year survival rate of invalids with ARL2-negative and BTG2-positive ndecreased(P<0.05).TNM stages Ⅲ～Ⅳ,high pathologicaon-small cell lung cancer increased significantly(P<0.05).The 5-year survival rate of non-small cell lung cancer invalids with tumor diameter≥3 cm, TNM stage Ⅲ～Ⅳ,infiltration depth≥1 cm, lymphatic vascular invasion, high pathological grade, recurrence, ARL2-positive, and BTG2-negative were l grade, ARL2 positive, and BTG2 negative are independent risk factors affecting the prognosis of patients with non-small cell lung cancer(P<0.05).Conclusion The expression of ARL2 protein in cancer tissues of patients with non-small cell lung cancer is increased, while the expression of BTG2 protein is decreased.ARL2 positive protein and BTG2 negative expression are independent risk factors affecting the prognosis of patients with non-small cell lung cancer.更多还原