【摘要】 目的 分析宫颈上皮内瘤变患者术后切缘阳性的危险因素及预后。方法 选取行手术治疗的宫颈上皮内瘤变患者260例作为研究对象，按照术后组织病理学检验结果，35例术后切缘阳性为阳性组，225例术后切缘阴性为阴性组。采用我院自制调查问卷，对患者年龄、绝经、病变大小、孕次、病变累及腺体、HPV感染、CIN分级信息进行收集，分析宫颈上皮内瘤变患者术后切缘阳性的影响因素及预后情况。结果 孕次、病变累及腺体、HPV感染、CIN分级是影响宫颈上皮内瘤变患者术后切缘阳性的单因素(P<0.05)。logistic回归分析显示，孕次≥3次、病变累及腺体、高危型HPV感染、CINⅢ级是宫颈上皮内瘤变患者术后切缘阳性的危险因素(P<0.05);阳性组复发率[12.50%(4/32)]较阴性组[0.90%(2/221)]高(P<0.05)。结论 针对宫颈上皮内瘤变患者术后切缘阳性的危险因素进行防治，可避免患者术后二次复发，提高预后效果。更多还原

【Abstract】 Objective To analyze the risk factors and prognosis of postoperative positive margin in patients with cervical intraepithelial neoplasia.Methods 260 patients with cervical intraepithelial neoplasia who underwent surgery were selected as the research objects.According to the results of postoperative histopathological examination, 35 cases with positive postoperative margin were regarded as the positive group and 225 cases with negative postoperative margin were regarded as the negative group.Using the self-made questionnaire, the age, menopause, lesion size, pregnancy times, lesion involved glands, HPV infection and CIN classification of patients were collected, and the influencing factors and prognosis of postoperative positive margin in patients with cervical intraepithelial neoplasia were analyzed.Results The number of pregnancies, lesions involving glands, HPV infection and CIN grade were the single factors affecting the positive margin of cervical intraepithelial neoplasia(P<0.05).Logistic regression analysis showed that the number of pregnancies ≥ 3,lesions involving glands, high-risk HPV infection and CIN ⅲ were the risk factors of positive margin in patients with cervical intraepithelial neoplasia(P<0.05);The recurrence rate of positive group was 12.50%(4/32) higher than that of negative group [0.90%(2/221)](P<0.05).Conclusion Prevention and treatment of the risk factors of positive margin in patients with cervical intraepithelial neoplasia can avoid the secondary recurrence and improve the prognosis.更多还原