【摘要】 目的 探讨CMYC和PD-L1表达与弥漫大B细胞淋巴瘤(DLBCL)临床病理特征及预后的关系。方法 选取DLBCL患者92例，免疫组化法检测CMYC及PD-L1蛋白的表达，分析其与DLBCL临床病理特征的关系。结果 92例DLBCL组织中72例CMYC蛋白为阳性，阳性率为78.3%, 76例PD-L1蛋白为阳性，阳性率为82.6%;Ann Arbor分期Ⅲ～Ⅳ期、有骨髓侵犯的DLBCL患者CMYC及PD-L1的表达阳性率显著高于Ann Arbor分期Ⅰ～Ⅱ期及无骨髓侵犯者(P均<0.05);预后不良组中CMYC及PD-L1的表达阳性率显著高于预后良好组，且Ann Arbor分期为Ⅲ～Ⅳ的患者占比显著高于预后良好组(P<0.05);Logistic回归分析发现，CMYC阳性、PD-L1阳性及Ann Arbor分期均是DLBCL预后不良的独立危险因素(P<0.05)。结论 CMYC及PD-L1蛋白在DLBCL患者中特异性高表达，且是DLBCL患者预后判断的潜在指标，值得临床推广应用。更多还原

【Abstract】 Objective To investigate the relationship between the expression of CMYC and PD-L1 andand clinical characteristics and prognosis of DLBCL patients.Methods The expression of CMYC and PD-L1 protein was detected by immunohistochemistry in 92 cases of DLBCL patients, and their relationship with the clinicopathological characteristics of DLBCL was analyzed.Results Among 92 DLBCL tissues, 72 were positive for CMYC protein, with a positive rate of 78.3%,and 76 were positive for PD-L1 protein, with a positive rate of 82.6%;The positive rates of CMYC and PD-L1 expression in DLBCL patients with Ann Arbor stage Ⅲ～Ⅳ and bone marrow invasion were significantly higher than those with Ann Arbor stage Ⅰ～Ⅱ and without bone marrow invasion(P<0.05).The percentage of patients with Ann Arbor stage Ⅲ～Ⅳ was significantly higher than that of patients with good prognosis(P<0.05);Logistic regression analysis revealed that CMYC positivity, PD-L1 positivity and Ann Arbor stage were independent risk factors for poor prognosis of DLBCL(P<0.05).Conclusion CMYC and PD-L1 proteins are specifically and highly expressed in DLBCL patients and are potential indicators for prognosis of DLBCL patients, which are worthy of clinical application.更多还原