【摘要】 肿瘤浸润淋巴细胞在肿瘤微环境中扮演着重要的角色,不同的细胞亚型在肿瘤的进展中发挥抗肿瘤或促肿瘤作用。肿瘤浸润淋巴细胞主要包括T淋巴细胞、B淋巴细胞和自然杀伤细胞,这些细胞可在多种因素的刺激下发生活化成熟及产生效应,参与肿瘤的免疫应答。长链非编码RNA(long non-coding RNA)是一类多效的调控因子,可参与机体内多种生理和病理过程。lncRNA可通过对细胞因子的调节参与肿瘤浸润淋巴细胞的成熟分化,同时参与相关免疫调节信号过程,调控机体的肿瘤免疫功能;lncRNA和肿瘤浸润淋巴细胞之间的调节机制尚未清楚。差异表达的lncRNA与肿瘤浸润淋巴细胞的相关性可作为肿瘤诊断和治疗的潜在靶点。更多还原

【Abstract】 Tumor infiltrating lymphocytes(TILs) exert a vital effect on the tumor microenvironment, and different cell subsets play anti-tumor or pro-tumor roles during tumor progression.TILs mainly include T lymphocytes, B lymphocytes and natural killer cells.These cells can mature, differentiate and take effect under the stimulation of various factors, which participate in the tumor immune response.Long non-coding RNA(lncRNA) is a group of pleiotropic regulators, which is associated with a variety of physiological and pathological processes.LncRNA can mediate the maturation and differentiation of TILs through regulating the release of cytokines and participate in relevant immunomodulatory signaling processes to regulate tumor immune function.Therefore, the correlation between aberrant expressed lncRNA and TILs might serve as a potential target of tumor diagnosis and treatment.更多还原