【摘要】 目的:生物信息学分析FERMT1在膀胱癌组织中的表达水平及其与病理参数的关系，并进而挖掘其突变信息及调控网络。方法:首先利用GEPIA数据库分析FERMT1在多种癌症中的表达水平，进而利用Oncomine及THPA等在线网站分析膀胱癌组织中FERMT1基因的mRNA及蛋白质表达情况；利用在线UALCAN数据库展现FERMT1与临床病理参数间的关系；cBioPortal在线数据库分析FERMT1基因的突变情况；LinkedOmics软件探究与FERMT1共表达的基因及基因富集分析。结果:FERMT1在多数癌症中呈现高表达，在膀胱癌组织中mRNA及蛋白水平均发生明显上调，且FERMT1表达水平与膀胱癌临床病理参数密切相关；同时，FERMT1基因发生多种类型的拷贝数突变，其中错义突变最为常见；FERMT1与多种基因存在共表达关系，进一步的富集分析展示这些基因在多种生物学过程中发挥重要作用。结论:本研究有效地揭示了FERMT1在膀胱癌组织中的表达信息及潜在的调控网络，为进一步研究FERMT1在膀胱癌组织发生发展中的作用奠定了理论基础。更多还原

【Abstract】 Objective:To analyze the expression level of FERMT1 in bladder cancer and its relationship with pathological parameters by bioinformatics, and to mine its mutation information and regulatory network.Methods:Firstly, the GEPIA database was used to analyze the expression level of FERMT1 in multiple cancers, and then online websites such as Oncomine and THPA were used to analyze the mRNA and protein expression of FERMT1 gene in bladder cancer.The online UALCAN database was used to show the relationship between FERMT1 and clinicopathologicalparameters relationship. cB ioP ortal online database analyzed the mutation of FERMT1 gene. LinkedO mics software explored the genes co-expressed with FERMT1 and gene enrichment analysis. Results: FERMT1 was highly expressed in most cancers,for bladder cancer,FERMT1 mRNA and protein levels were significantly up-regulated which was closely related to the clinicopathological parameters. At the same time,several types of copy number mutations occurred in FERMT1 gene,and missense mutations were the most common. FERMT1 co-expressed with a variety of genes,and further enrichment analysis shows that these genes played an important role in a variety of biological processes. Conclusion: This study effectively revealed the expression information and potential regulatory network of FERMT1 in bladder cancer,laying a theoretical foundation for further research on the role of FERMT1 in the development of bladder cancer.更多还原