【摘要】 N,N,N’,N’-四（β-羟丙基）己二酰胺（简称“1260”）是一种新型的粉末涂料固化剂，其性能优于N,N,N’,N’-四（β-羟乙基）己二酰胺（简称“552”）。用己二酸二甲酯和二异丙醇胺一步反应合成“1260”，反应转化率100%，反应纯度80.6%。本文设计正交试验，通过HPLC检测研究了温度、投料比、催化剂用量及反应时间等参数对反应的影响；同时对后处理工艺进行研究。结果表明，最优反应条件为己二酸二甲酯∶二异丙醇胺投料比1.0∶3.4、催化剂添加量6%、反应时间16 h、反应温度140℃，通过结晶纯化获得白色固体产品，收率58.9%；产物结构经1H NMR和LC-MS确证。更多还原

【Abstract】 N,N,N’,N’-tetra(β-hydroxypropyl) hexanediamide(referred to as “1260”) is a new kind of curing agent for powdercoatings,and its properties are better than N,N,N’,N’-tetra(β-hydroxyethyl)hexanediamide(referred to as “552”).“1260” was synthesized by one-step reaction of dimethyl adipate and diisopropanolamine with the reaction conversion rate of 100% and reaction purity of 80.6%.The effects of temperature,material ratio,catalyst dosage,contact time and other parameters on the reaction were studied by HPLC,and orthogonal experiments was designed in this paper.Meanwhile,the post-treatment technology is studied,the results show that under the optimal reaction conditions(the ratio of feeding dimethyl adipate and diisopropanolamine is 1.0 to 3.4,dosage of catalyst 6%,reaction time 16 h,reaction temperature 140 ℃),the white solid product was obtained by crystallization and purification,with a crystallization yield of 58.9%.The structure of the product was confirmed by 1 H NMR and LC-MS.更多还原