【摘要】 目的 基于国际骨质疏松基金会(IOF)的骨质疏松风险1分钟测试题探究绝经前后女性骨密度及骨质疏松发生的早期风险因素的关联，为早发现骨量下降，预防骨质疏松提供依据。方法 通过问诊及电子问卷填写的方式收集2019-06-01-2021-09-30绵阳市中心医院就诊的绝经期前后女性的人口学资料、既往史、IOF测试题及骨密度等信息，共纳入研究对象282名，其中绝经前人群118(41.8%)名，绝经人群164(58.2%)名。首先对绝经前后女性骨密度及潜在风险因素分布情况进行描述性分析，进一步通过多重线性回归分别在绝经前人群和绝经后人群中探究IOF测试题潜在风险因素与Z值或T值的关联。结果 在绝经前人群中，父母亲曾诊断有骨质疏松或有轻摔后骨折史与Z值存在负相关(β=0.206,95%CI:-0.907～-0.101),父母亲中有一人驼背与Z值存在负相关(β=0.266,95%CI:-1.103～-0.063)。在绝经后人群中，年龄与T值呈负相关(β=-0.078,95%CI:-0.116～-0.040);父母亲中有一人驼背与T值存在负相关(β=-0.461,95%CI:-0.913～-0.009);≤45岁就停经与t值呈负相关(β=-0.556,95%CI:-0.981～-0.131)。结论 绝经前人群中，若存在骨折家族史及父母亲驼背者，提示骨量丢失的风险越高；而对于绝经后人群，除父母亲驼背及高龄外，相比于正常年龄绝经人群，过早绝经的人群骨量丢失的风险较高。更多还原

【Abstract】 Objective This study was based on the osteoporosis risk one-minute test of the International Osteoporosis Foundation(IOF) to explore the association between bone density and early risk factors among pre-menopausal and post-menopausal females, so as to provide a basis for early detection of bone mass decline and prevention of osteoporosis.Methods The demographic information, past medical history, IOF test, bone mineral density, and other information of pre-and post-menopausal females treated at Mianyang Central Hospital from 1 June 2019 to 30 September 2021 were collected through consultation and electronic questionnaire.A total of 282 subjects were included in the study, including 118(41.8%) premenopausal and 164(58.2%) postmenopausal people.Firstly, the bone density and its potential risk factors of pre-menopausal and post-menopausal female participants were conducted a descriptive analysis.Secondly, the association between bone mineral density Z scores or T scores and potential risk factors involved in the IOF test was estimated using multiple linear regression models among pre-menopausal and post-menopausal participants.Results For the premenopausal participants, parents had a history of osteoporosis or fracture after light fall, which was negatively correlated with the bone mineral density Z value(β=0.206,95%CI:-0.907--0.101).One of the parents had a hunchback,which was negatively correlated with the Z value(β=0.266,95%CI:-1.103--0.063).For postmenopausal participants,age was negatively correlated with the bone mineral density t value(β=-0.078,95%CI:-0.116--0.040).There was a negative correlation between parent’s hunchback and t value(β=-0.461,95%CI:-0.913--0.009).Menopause at or before age 45was negatively correlated with the t value(β=-0.556,95%CI:-0.981--0.131).Conclusions Among premenopausal females,the family history of fracture and parental hunchback suggested a high risk of bone mass loss.In addition to parental hunchback and advanced age,postmenopausal females with premature menopause may have a higher risk of bone loss compared to postmenopausal females with normal-age menopause.更多还原