【摘要】 代谢组学是一门对某一生物或细胞所有低分子质量代谢产物（以相对分子质量<1 000的有机和无机的代谢物为研究核心区）进行分析的新兴学科，是一种通过研究代谢产物揭示机体生命活动代谢本质的科学方法。针灸学作为中医学的重要组成部分，遵循整体观念和辨证论治原则，针刺效应的多层次、多靶点整体特性与代谢组学的整体性、系统性十分吻合，代谢组学在针灸效应机制研究中具有广阔的应用前景。目前，针灸学在国际标准化进程中的发展机遇与挑战并存，运用代谢组学技术全方面、系统性阐释针灸效应机制的科学内涵对针灸学现代化发展具有重要意义，代谢组学技术的应用或能够为客观科学地阐明针灸效应机制提供重要的技术支持。更多还原

【Abstract】 Metabolomics is an emerging discipline that analyzes all low molecular weight metabolites(organic and inorganic metabolites with relative molecular mass below 1,000 as the research core)of a certain organism or cell,and is a scientific method that reveals the metabolic essence of the organism’s life activities through the study of metabolites. Science of acupuncture and moxibustion,as an important part of traditional Chinese medicine,follows the principle of holistic concept and syndrome differentiation based treatment. The multi-level and multi-target characteristics of acupuncture effect are highly consistent with the integrity and systematicness of metabolomics,which has a broad application prospect in the effect mechanism study of acupuncture and moxibustion. At present,there are both opportunities and challenges for the development of acupuncture and moxibustion in the process of international standardization. The application of metabolomics technology to elucidate the scientific connotation of effect mechanism of acupuncture and moxibustion in a comprehensive and systematic manner is of great significance for the modernization of acupuncture and moxibustion,and the use of metabolomics technology may also provide important technical support for the objective and scientific explanation of the effect mechanism.更多还原