【摘要】 目的 观察穴位贴敷联合芩栀清胰饮治疗急性胰腺炎(SAP)的临床疗效及对患者胃肠功能的影响。方法选取SAP患者140例,随机分为对照组和研究组,每组70例。对照组采用常规西医治疗,研究组在常规西医治疗基础上,采用穴位贴敷联合芩栀清胰饮治疗。观察两组胃肠功能指标(胃肠蠕动、肠鸣音、自主排便、自主排气恢复时间)、实验室指标[血淀粉酶、尿淀粉酶、C反应蛋白(CRP)、天门冬氨酸氨基转移酶(AST)、血尿素氮(BUN)],并比较两组的临床疗效及不良反应发生情况。结果 研究组总有效率明显高于对照组(P<0.05)。研究组胃肠蠕动、肠鸣音、自主排便、自主排气恢复时间短于对照组(P<0.05)。研究组治疗后血淀粉酶、尿淀粉酶、CRP、AST、BUN低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 在常规西医治疗基础上,穴位贴敷联合芩栀清胰饮治疗SAP,可促进胃肠功能恢复,其主要作用机制可能与改善血淀粉酶、尿淀粉酶、CRP、AST、BUN水平有关。更多还原

【Abstract】 Objective To observe the clinical efficacy of acupoint sticking therapy plus Qin Zhi Qing Yi Yin in treating severe acute pancreatitis(SAP) and its effect on the patients’ gastrointestinal function. Method A total of 140patients with SAP were randomized into a control group and a study group, with 70 cases in each group. The control group was intervened by routine Western medicine treatment, and the study group received the routine Western medicine treatment plus acupoint sticking therapy and Qin Zhi Qing Yi Yin. The gastrointestinal function indicators(time in recovering gastrointestinal peristalsis, bowel sounds, spontaneous defecation, and expelling gas) and laboratory indexes [blood amylase, urine amylase, C-reactive protein(CRP), aspartate aminotransferase(AST), and blood urea nitrogen(BUN)] were observed for the two groups. The clinical efficacy and adverse reactions were also compared between the two groups. Result The total effective rate was significantly higher in the study group than in the control group(P<0.05). The study group took a shorter time in recovering gastrointestinal peristalsis, bowel sounds,spontaneous defecation, and expelling gas compared with the control group(P<0.05). After the treatment, the levels of blood amylase, urine amylase, CRP, AST, and BUN in the study group were lower than those in the control group(P<0.05). There was no significant difference in the adverse reaction rate between the two groups(P>0.05). Conclusion Based on the Western medicine treatment, acupoint sticking therapy plus Qin Zhi Qing Yi Yin can boost the recovery of gastrointestinal function in treating SAP, and the main mechanism may be associated with the improvements of blood amylase, urine amylase, CRP, AST, and BUN levels.更多还原