【摘要】 目的:探讨子宫肌瘤对子宫内膜样癌临床病理特征及预后的影响。方法:回顾性分析2010年9月22日至2016年9月7日在青岛大学附属医院接受手术治疗后病理诊断为子宫内膜样癌1024例患者的临床资料，分为合并子宫肌瘤组(457例)和未合并子宫肌瘤组(567例)。比较两组患者的临床病理特征及预后。结果:(1)与未合并子宫肌瘤组相比，合并子宫肌瘤组的患者绝经年龄晚，合并糖尿病的比例低，既往有子宫肌瘤病史的患者比例高，差异均有统计学意义(P<0.05);(2)与未合并子宫肌瘤组比较，合并子宫肌瘤组中肿瘤分期为Ⅰ期的比例较高、组织分级为G1级的比例较高、淋巴结转移率较低，差异有统计学意义(P<0.05);(3)合并子宫肌瘤组患者的复发率低于未合并子宫肌瘤组(P<0.05),但两组的5年无病生存率、5年总存活率差异无统计学意义(P>0.05)。结论:子宫肌瘤可能有利于减缓子宫内膜癌的进展，子宫肌瘤是否是子宫内膜样癌预后良好的保护因素，有待进一步研究。更多还原

【Abstract】 Objective:To investigate the effect of uterine fibroids on the clinicopathological characteristics and prognosis of endometrioid adenocarcinoma.Methods:A retrospective analysis was performed on the clinical data of 1024 patients with endometrioid adenocarcinoma who had received surgical treatment in the Affiliated Hospital of Qingdao University from September 22 nd, 2010 to September 7 th, 2016.The patients were divided into two groups: the combined fibroid group(n=457)and the uncomplicated fibroid group(n=567).And then, we compared the clinicopathological characteristics and prognosis of the two groups.Results:(1)Compared with the group without uterine fibroids, patients with fibroids had a later age at menopause, a lower proportion of combined diabetes mellitus, and a higher proportion to have a previous history of fibroids.All differences were statistically significant(P<0.05).(2)Compared with the uncomplicated fibroid group, the combined fibroid group had a higher proportion of tumor stage I,a higher proportion of tissue grade G1,and a lower rate of lymph node metastasis, and the differences were statistically significant(P<0.05).(3)The recurrence rate of patients in the combined fibroid group was lower than that in the uncomplicated fibroid group(P<0.05),but the differences in the 5-year disease-free survival rate and 5-year overall survival rate between the two groups were not statistically significant(P>0.05).Conclusions:Uterine fibroids may be beneficial in slowing the progression of endometrial carcinoma.Whether fibroids are a protective factor for a good prognosis of endometrioid adenocarcinoma needs further study.更多还原