【摘要】 目的 分析新型冠状病毒疫苗（新冠疫苗）加强针接种者血清新型冠状病毒（新冠）抗体IgG检测结果，为接种新冠疫苗加强针提供依据。方法 已接种新冠疫苗的健康接种者314例，依据接种情况分为加强针组、两剂小于180天组、两剂大于180天组。加强针组为接种新冠疫苗加强针后1周～2月者，共205例；两剂小于180天组为完成两剂新冠疫苗接种后<180 d者，共49例；两剂大于180天组为完成两剂新冠疫苗接种后>180 d者，共60例。采用胶体金法测算三组接种者血清新冠抗体IgG阳性率。结果 加强针组血清新冠抗体IgG阳性率为83.9%，两剂小于180天组血清新冠抗体IgG阳性率为18.4%，两剂大于180天组血清新冠抗体IgG阳性率为5.0%，两两比较，P均<0.05。加强针接种>1月者血清新冠抗体IgG阳性率为85.2%，加强针接种<1月者血清新冠抗体IgG阳性率为75.9%，两者相比，P>0.05。加强针组接种者中男性血清新冠抗体IgG阳性率为85.1%，女性血清新冠抗体IgG阳性率为82.4%，两者相比，P>0.05。加强针组接种者中18～50岁者血清新冠抗体IgG阳性率为86.0%,>50岁者血清新冠抗体IgG阳性率为58.3%，两者相比，P<0.05。结论 与接种两剂新冠疫苗相比，接种新冠疫苗加强针可显著提升新冠抗体IgG阳性率，免疫保护作用更强。接种新冠疫苗加强针后，年龄>50岁者接种新冠疫苗加强针后新冠抗体IgG阳性率低于18～50岁者。更多还原

【Abstract】 Objective To analyze IgG test results of serum SARS-CoV-2 antibody in people after booster vaccinations against SARS-CoV-2,and to provide a basis for the booster vaccination.Methods There were 314 healthy individuals who had been vaccinated with the COVID-19 vaccine.Depending on their inoculation situation,they were divided into three groups:the booster injection group(1 week to 2 months after booster vaccination) of 205 cases,<180 days after two doses group(<180 days after two doses of COVID-19 vaccine) of 49 cases,and>180 days after two doses group(>180 days after two doses of COVID-19 vaccine) of 60 cases.The positive rate of IgG in serum of the three groups was measured using the colloidal gold method.Results The serum COVID-19 antibody IgG positive rates were 83.9% in the booster injection group,18.4% in the <180 days after two doses group,and 5.0% in the>180 days after two doses group,with statistically significant difference between any two groups(all P<0.05).In the booster injection group,the serum COVID-19 antibody IgG positive rate was 85.2% in people who received a booster injection more than a month,while those who received a booster injection less than a month had a positive rate of 75.9%,and there was no significant difference between these two groups(P>0.05).In the booster injection group,the positive rates of serum COVID-19 antibody IgG were85.1% in males and 82.4% in females,with no significant difference(P>0.05).In the booster injection group,people at the age of 18 and 50 had a positive serum COVID-19 antibody IgG rate of 86.0%,while those over 50 had a positive rate of58.3%,and there was significant difference between them(P<0.05).Conclusions Compared with two injections of the COVID-19 vaccine,the booster injection can significantly increase the positive rate of the antibody IgG of COVID-19,which results in a stronger immune response.There is a lower IgG positive rate of COVID-19 antibodies in those aged over50 years following the booster dose of COVID-19 vaccine than in those aged 18-50 years.更多还原