【摘要】 以(1S,2S)-1-(4-硝基苯基)-2-氨基-1,3-丙二醇(氯霉胺)为原料，首先制备(1S,2S)-1-(4-硝基苯基)-2-二甲氨基-1,3丙二醇，再用Zn粉和浓盐酸作为还原剂，还原后得到(1S,2S)-1-(4-氨基苯基)-2-二甲氨基-1,3丙二醇，经重氮化反应后，再与三苯基氯甲烷反应，最终得到目标产物(1S,2S)-1-苯基-2-二甲氨基-3-苯基甲氧基-1-丙醇，其结构经1H NMR,13C NMR,HRMS表征确定。更多还原

【Abstract】 ( 1S,2S)-1-( 4-nitro Phenyl)-2-dimethylamino-1,3 propanediol has been synthezied using chloramphenicol as starting material,then was treated with Zn powder and concentrated hydrochloric acid to obtain( 1S,2S)-1-( 4-aminophenyl)-2-dimethylamino.The intermediate was tansfered to target product( 1S,2S)-1-phenyl-2-dimethylamino-3-phenylmethoxy after diazotization reaction and nucleophilic substitution reaction with triphenylchloromethane.The structure of tarrget product was confirmed by1H NMR,13C NMR,and HRMS characterization.更多还原