【摘要】 目的 使用经颅彩色多普勒超声观察烟雾血管病患者（MMA）眼动脉（OA）的血流动力学变化与临床分期之间是否存在相关性。方法 连续纳入我院神经外科就诊并经脑血管造影（DSA）确诊的MMA患者，根据DSA图像对所有患病侧进行Suzuki分期，并测量其同侧眼动脉的收缩期峰值流速(PSV_OA)及搏动指数(PI_OA)。结果 本研究最终纳入MMA患者48例，共90侧大脑半球存在烟雾血管表现。其中，病程处于早期（SuzukiⅠ-Ⅱ期）、中期（SuzukiⅢ-Ⅳ期）、晚期（SuzukiⅤ-Ⅵ期）的大脑半球分别为23个，23个和44个，其眼动脉均表现为PSV_OA加快，PI_OA降低。早、中、晚期三组患者间PSV_OA的差异无统计学意义（P>0.05）,三组患者间PIOA差异存在统计学意义（P<0.001）,且两两比较差异均有统计学意义（P<0.05）,分期越晚者PI_OA越低。Spearman相关分析显示，PI_OA与病程分期之间呈中等程度的负相关，相关系数为-0.511（P<0.001）。结论 本研究初步证实PI_OA与MMA患者的临床分期存在一定的相关性，PI_OA越低，临床分期越晚，对其进行动态观察可能有助于医生临床策略的确定。更多还原

【Abstract】 Objective To observe the correlation between the hemodynamic changes of ophthalmic artery（OA） and clinical stage in patients with moyamoya angiopathy（MMA） by transcranial color Doppler ultrasound. Methods Patients with MMA diagnosed by digital subtract angiography（DSA） in our hospital were included. Suzuki staging was performed on all affected sides according to DSA images, and the systolic peak velocity(PSA_OA) and pulsatile index(PI_OA) of ipsilateral ophthalmic arteries were measured. Results 48 MMA patients were included in the study, with a total of 90 cerebral hemispheres with moyamoya vascular manifestations. Among them, there were 23, 23 and 44 cerebral hemispheres in the early stage（Suzuki stage Ⅰ-Ⅱ）, middle stage（Suzuki stage Ⅲ-Ⅳ） and late stage（Suzuki stage Ⅴ-Ⅵ）, respectively. The ophthalmic arteries showed accelerated PSA_OA and decreased PI_OA. There was no significant difference in PSA_OA among the three groups（P>0.05）. There were significant differences in PI_OA among the three groups（P<0.001）, and between every two groups（P<0.05）. The later the stage, the lower the PI_OA. Spearman correlation analysis showed that there was a moderate negative correlation between PI_OA and the groups, and the correlation coefficient was-0.511（P<0.001）.Conclusion This study preliminarily confirms that there is a certain correlation between PI_OA and clinical stage of MMA patients. The lower the PI_OA, the later the clinical stage. Dynamic observation may help doctors to determine clinical strategies.更多还原