【摘要】 微重力是太空环境与地球环境重要差别之一，宇航员因此受到的影响包括认知下降、心血管功能障碍、骨骼肌肉流失、免疫系统损伤等。基因是决定细胞功能的根本，微重力通过对基因表达的调控，影响着整个机体的稳态。多种细胞中多种基因对于微重力的响应程度存在异同，本文综述了近年来微重力对多种组织细胞中基因转录调控的研究结果，总结了微重力影响基因表达的可能机制，为认知生命发展进程和保障航天员身心健康提供参考。更多还原

【Abstract】 Microgravity is one of the important differences between the space environment and the Earth environment, and astronauts suffer from the resulting effects including cognitive decline, cardiovascular dysfunction, skeletal muscle loss, and immune system damage. Genes are fundamental to cellular function, and microgravity affects the homeostasis of the entire organism through the regulation of gene expression. This paper reviews the results of recent studies on the regulation of gene transcription in a variety of tissue cells and summarizes the possible mechanisms by which microgravity affects gene expression,providing a reference for cognitive evolution of life development and safeguarding the physical and mental health of space researchers.更多还原