【摘要】 【目的】探讨参苓降酸煮散联合非布司他片治疗脾虚湿蕴型高尿酸血症无症状期患者的临床疗效。【方法】采用回顾性研究方法，根据用药情况将80例脾虚湿蕴型高尿酸血症无症状期患者分为观察组和对照组，每组各40例。观察组给予参苓降酸煮散联合非布司他片治疗，对照组给予非布司他片治疗，疗程为8周。观察2组患者治疗前后中医证候积分和血清尿酸水平的变化情况，评价2组患者的中医证候疗效、痛风发生率和安全性。【结果】（1）经治疗8周后，观察组的总有效率为87.50%(35/40)，对照组为45.00%(18/40)，组间比较，观察组的中医证候疗效明显优于对照组（P<0.01）。（2）治疗后，2组患者的中医证候积分均较治疗前明显下降（P<0.05），且观察组对中医证候积分的下降作用明显优于对照组（P<0.05）。（3）治疗后，2组患者的血清尿酸水平均较治疗前明显下降（P<0.05），且观察组对血清尿酸水平的下降作用明显优于对照组（P<0.05）。（4）在治疗后的2个月内，观察组患者的痛风发生率为0，明显低于对照组的15.00%(6/40)，组间比较，差异有统计学意义（P<0.05）。（5）治疗过程中，2组患者均未发生明显不良反应，具有较高的安全性。【结论】参苓降酸煮散联合非布司他片治疗脾虚湿蕴型高尿酸血症无症状期患者疗效确切，其在改善中医证候、降低血清尿酸水平方面的作用优于单纯非布司他片治疗，同时在减少痛风发作及用药安全方面也有一定的优势。更多还原

【Abstract】 Objective To investigate the clinical efficacy of Shen Ling Jiangsuan Tea Drink combined with Febuxostat Tablets in treating patients with hyperuricemia of spleen deficiency with dampness accumulation syndrome type at asymptomatic stage. Methods A retrospective method was conducted in 80 patients with hyperuricemia of spleen deficiency with dampness accumulation syndrome type at asymptomatic stage. The patients were divided into observation group and control group according to the administration,with 40 cases in each group.The observation group was given Shen Ling Jiangsuan Tea Drink combined with Febuxostat Tablets, while the control group was given Febuxostat Tablets alone. The treatment for both groups lasted for 8 weeks. The changes in traditional Chinese medicine(TCM)syndrome scores and serum uric acid level in the two groups were observed before and after treatment,and then the TCM syndrome efficacy,incidence of gout and clinical safety in the two groups were evaluated. Results(1)After 8 weeks of treatment,the overall effective rate of the observation group was 87.50%(35/40)while the control group was 45.00%(18/40). The intergroup comparison showed that the TCM syndrome efficacy in the observation group was significantly superior to that in the control group(P<0.01).(2)After treatment,the TCM syndrome scores of patients in both groups were significantly decreased compared with those before treatment(P<0.05),and the effect on decreasing TCM syndrome scores in the observation group was significantly superior to that in the control group(P<0.05).(3)After treatment,the serum uric acid level in both groups was significantly decreased compared with that before treatment(P<0.05), and the effect on decreasing serum uric acid level in the observation group was significantly superior to that in the control group(P<0.05).(4)Within 2 months of treatment,the incidence of gout in the observation group was zero,which was significantly lower than that in the control group [15.00%(6/40)],and the intergroup comparison showed that the difference was statistically significant(P<0.05).(5)During the treatment, there were no significant adverse reactions occurring in any of the patients in the two groups,which indicated a high safety profile. Conclusion Shen Ling Jiangsuan Tea Drink combined with Febuxostat Tablets exert certain effect in treating patients with hyperuricemia of spleen deficiency with dampness accumulation syndrome type. The combined therapy is more effective on improving the TCM syndrome and lowering the serum uric acid level than Febuxostat Tablets alone,and it also has certain advantages in reducing gout attacks and medication safety.更多还原