【摘要】 【目的】探讨轻度认知障碍（MCI）患者中医体质分布情况及其认知功能与血清尿酸（UA）、超氧化物歧化酶（SOD）的相关性。【方法】以2020年8月至2021年6月广州中医药大学第二附属医院收治的118例MCI患者作为观察组，同时以该院同期体检的120例正常人作为对照组。比较2组的中医体质分型分布情况及蒙特利尔认知评估量表（MoCA）评分、血清UA、SOD水平差异，并采用Pearson相关性分析探讨MCI患者认知功能与血清UA、SOD的相关性。【结果】（1）观察组的气虚质（42.37%）、阳虚质（20.34%）分布比例分别高于对照组的29.17%、10.83%，差异有统计学意义（P<0.05）；而观察组的阴虚质（4.24%）分布比例低于对照组的14.17%，差异有统计学意义（P<0.01）。（2）观察组的MoCA评分和血清SOD水平明显低于对照组，血清UA水平明显高于对照组，差异均有统计学意义（P<0.01）。（3）经Pearson相关性分析，MCI患者的MoCA评分与血清UA、SOD均呈显著正相关性（r=0.587,P=0.006;r=0.538,P=0.012）。【结论】气虚、阳虚体质者更易发生MCI，阴虚体质者最不容易发生MCI;MCI患者的MoCA评分与血清UA、SOD水平密切相关。更多还原

【Abstract】 Objective To investigate the distribution of traditional Chinese medicine(TCM)constitution in the patients with mild cognitive impairment(MCI),and to study the correlation of cognitive function with serum uric acid(UA)and superoxide dismutase(SOD). Methods A total of 118 MCI patients admitted to the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from August 2020 to June 2021 were selected as the observation group, and 120 normal subjects who underwent physical examination during the same period were selected as the control group. The distribution of TCM constitution types,Montreal Cognitive Assessment Scale(MoCA)scores,and serum UA and SOD levels were compared between the two groups,and the correlation of the cognitive function of MCI patients with serum UA and SOD was explored by Pearson correlation analysis. Results(1)The proportions of qi deficiency constitution(42.37%)and yang deficiency constitution(20.34%)in the observation group were higher than those in the control group(being 29.17% and 10.83%,respectively),and statistically significant differences were shown in the proportions of qi deficiency constitution and yang deficiency constitution between the two groups(P<0.05). The proportion of yin deficiency constitution(4.24%)in the observation group was lower than that in the control group(being 14.17%),and the difference of the proportion of yin deficiency between the two groups was statistically significant(P<0.01).(2)MoCA scores and serum SOD level in the observation group were significantly lower than those in the control group, while serum UA level was significantly higher than that in the control group,the differences being statistically significant(P<0.01).(3)Pearson correlation analysis showed that the MoCA scores of MCI patients were significantly positively correlated with serum UA(r = 0.587,P = 0.006)and SOD(r = 0.538,P = 0.012). Conclusion Patients with qi deficiency and yang deficiency constitution are more likely to develop into MCI,while those with yin deficiency constitution are least likely to develop into MCI. MoCA scores of MCI patients are closely related with serum UA and SOD levels.更多还原