【摘要】 目的 研究全麻诱导靶控输注丙泊酚4.0μg/ml时，中年与老年患者置入喉罩时阿芬太尼的半数有效量(ED₅₀)。方法 纳入择期行下肢静脉手术及泌尿外科碎石手术的患者40例，按照年龄分为中年组（40～59岁）和老年组（60～79岁），每组20例。全麻诱导以4.0μg/ml靶控输注丙泊酚，采用改良的probit序贯法确定两组置入喉罩时阿芬太尼的ED₅₀。结果 靶控输注丙泊酚4.0μg/ml时，中年组阿芬太尼的ED₅₀为13.18μg/kg（95%CI11.80～19.87）；老年组阿芬太尼的ED₅₀为10.13μg/kg（95%CI 9.10～12.19）。中年组阿芬太尼的ED₅₀高于老年组。结论 靶控输注丙泊酚4.0μg/ml时，中年组阿芬太尼用于喉罩置入时的ED₅₀为13.18μg/kg，老年组的ED₅₀为10.13μg/kg。更多还原

【Abstract】 Objective To study the median effective dose(ED₅₀) of alfentanil during laryngeal mask insertion in middle-aged and elderly patients with target-controlled infusion of propofol 4.0 μg/ml induced by general anesthesia.Methods Forty patients undergoing elective lower limb venous surgery and urological lithotripsy were included.They were divided into middle-aged group（40-59 years）and elderly group（60-79 years）according to their age,with 20patients in each group.General anesthesia was induced with 4.0 μg/ml target-controlled infusion of propofol,and a modified probit sequential method was used to determine the ED₅₀of alfentanil for laryngeal mask insertion in both groups.Results The ED₅₀of alfentanil in the middle-aged group was 13.18 μg/kg（95%CI 11.80-19.87）and 10.13 μg/kg（95%CI 9.10-12.19）when target-controlled infusion of propofol was 4.0 μg/ml.The ED₅₀ of alfentanil was higher in the middle-aged group than in the older group. Conclusion When target-controlled infusion of propofol was 4.0 μg/ml,the ED₅₀of alfentanil for laryngeal mask insertion was 13.18 μg/kg in the middle-aged group and 10.13 μg/kg in the elderly group.更多还原