【摘要】 目的 探讨REDCap数据库在持续气道正压通气(CPAP)干预下对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者认知功能影响随访系统的临床应用。方法 构建基于REDCap数据库的CPAP干预对OSAHS患者认知功能影响随访系统,对每例受试者采集基本信息、病史资料、初始入组、入组后第1、6、12月四个时间点的PSG检查、MoCA问卷、MMSE问卷、神经行为学测试、MRS和fMRI、行为学测试等信息。总结从2020年1月至2021年3月我院耳鼻咽喉头颈外科基于REDCap数据库的CPAP干预对OSAHS患者认知功能影响随访系统使用情况。结果 基于REDCap的CPAP干预对OSAHS患者认知功能影响随访系统能够实现受试者的电子数据采集,多用户、多地点信息录入,数据筛选,数据导出和分析,质控及权限设置,构建随访工作日历等。随访系统中共收集74例CPAP干预的OSAHS患者与74例非CPAP干预的OSAHS患者的临床资料进行随机对照研究。结论 基于REDcap数据库的CPAP干预对OSAHS患者认知功能影响随访系统平台的搭建为项目管理提供了支撑。其便于追踪管理及维护,可为医学研究人员开展相关调查研究提供一个便利、高效、安全及标准化的数据管理工具。更多还原

【Abstract】 Objective To explore the clinical application of the REDCap database in the follow-up system of continuous positive airway pressure(CPAP) on the cognitive function of patients with obstructive sleep apneahypopnea syndrome(OSAHS). Methods We constructed a follow-up system for the CPAP intervention impact on OSAHS patients’ cognitive function based on the REDCap database. We collected basic information, medical history, PSG, MoCA test, MMSE test, neurobehavioral test, MRS and fMRI, behavioural test and other information for each subject at four-time points(initial enrollment, first month, sixth months and twelfth months). We summarised the usage of this follow-up system in our hospital’s Otorhinolaryngology-Head and Neck Surgery Department from January 2020 to March 2021. Results Effects of redcap based CPAP intervention on cognitive function in patients with OSAHS the follow-up system enables electronic data capture, multi-user, multi-site information entry, data screening, data export and analysis, quality control and authority setting and construction of a follow-up work calendar. A total of 74 clinical data of CPAP intervened OSAHS patients compared with 74 non-CPAP intervened OSAHS patients were collected in the follow-up system for a randomised controlled study.Conclusion The establishment of the follow-up system for the CPAP intervention’s impact on OSAHS patients’ cognitive function based on the REDcap database supports the project management. Its easy tracking management and maintenance could provide a convenient, efficient, safe and standardised data management tool for medical researchers to carry out related investigations and research.更多还原