【摘要】 目的 观察小青龙汤合苍耳子散加减辅治儿童变应性鼻炎的临床效果与安全性。方法 选取2017年1月—2020年12月乳山市中医院就诊的变应性鼻炎患儿100例为研究对象，依据随机数字表法分为观察组和对照组，每组50例。对照组给予西药治疗，观察组在对照组用药基础上使用小青龙汤合苍耳子散加减治疗，2组均连续用药18 d。比较2组患儿治疗总有效率，治疗前后各项典型临床症状（打喷嚏、鼻塞、鼻痒、流涕）积分、血清炎性因子[白介素-10(IL-10)、白介素-33(IL-33)、转化生长因子-β1(TGF-β1)、细胞间黏附分子-1(ICAM-1)]水平变化，以及治疗过程中不良反应。结果 观察组患儿治疗总有效率为96.00%，高于对照组的84.00%（χ~2=4.000,P=0.046）；治疗18 d后，2组打喷嚏、鼻塞、鼻痒、流涕积分均较治疗前下降，且观察组低于对照组（P均<0.01）;2组IL-10、TGF-β1水平较治疗前升高，IL-33、ICAM-1水平较治疗前降低，且观察组升高/降低幅度大于对照组（P均<0.01）;2组治疗过程中不良反应总发生率比较差异无统计学意义（χ~2=0.444,P=0.505）。结论 对于罹患变应性鼻炎的患儿，在常规西药治疗基础上联合使用小青龙汤合苍耳子散加减，有助于改善患儿的临床症状积分及血清学指标，有效提升治疗效果，且具备良好的安全性。更多还原

【Abstract】 Objective To observe the the clinical effect ofXiaoqinglongdecoction combined withXanthiumpowder in the treatment of allergic rhinitis in children.Methods A total of 100 children with allergic rhinitis who were treated in Rushan Hospital of Traditional Chinese Medicine from January 2017 to December 2020 were selected as the research objects,and divided into observation group and control group according to the random number table method, with 50 cases in each group. The control group was treated with western medicine, the observation group usedXiaoqinglongdecoction andXanthium powder on the basis of the control group, both groups were treated with medication for 18 consecutive days. The total effective rate of treatment, the scores of typical clinical symptoms(sneezing, nasal congestion, nasal itching, runny nose), serum inflammatory factors[interleukin-10(IL-10), interleukin-33(IL-33), transforming growth factor-β1(TGF-β1), intercellular adhesion molecule-1(ICAM-1)] level changes were compared between the two groups before and after treatment, and adverse reactions during treatment.Results The total effective rate of children in the observation group was 96. 00%, which was higher than 84. 00% in the control group（χ~2= 4. 000,P= 0. 046）. After 18 days of treatment, the scores of sneezing, nasal congestion, nasal itching and runny nose in the two groups were all decreased compared with those before treatment, and the observation group was lower than the control group(all P< 0. 01); Compared with before treatment, the levels of IL-33 and ICAM-1 decreased, and the increase/decrease in the observation group was greater than that in the control group(all P<0. 01). There was no significant difference in the total incidence of adverse reactions between the two groups during treatment（χ~2= 0. 444,P= 0. 505）.Conclusion For children suffering from allergic rhinitis, on the basis of conventional western medicine treatment, the combined use ofXiaoqinglongdecoction andXanthiumpowder can help improve the children′ s clinical symptom scores and serological indicators, and effectively improve them. It can effectively improve the treatment effect and has good safety.更多还原