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理气活血滴丸治疗慢性稳定性心绞痛的有效性和安全性

Efficacy and safety of Liqihuoxue dripping pills in the treatment of chronic stable angina pectoris

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【作者】 张雪娟吴宗贵毕育学于宁王晓峰

【Author】 ZHANG Xuejuan;WU Zonggui;BI Yuxue;YU Ning;WANG Xiaofeng;Department of General Internal Medicine,the Affiliated Hospital of Qingdao University;

【通讯作者】 王晓峰;

【机构】 青岛大学附属医院综合内科海军医科大学附属长征医院心血管内科西安交通大学医学院贵州益佰制药股份有限公司医学部新疆医科大学附属中医医院心内科

【摘要】 目的 观察理气活血滴丸治疗慢性稳定性心绞痛的有效性和安全性。方法 选取2016年4月在青岛大学附属医院综合内科就诊的慢性稳定性心绞痛患者204例,口服理气活血滴丸,每次10粒,每天3次,连服4周进行治疗。评估患者疗效、安全性和生活质量等指标。结果 服用4周末,心绞痛症状有效率91.66%,心电图疗效有效率65.69%,硝酸甘油停减率67.15%。共发生不良事件22例(10.78%),与药物可能有关的不良事件4例(1.96%)。治疗4周末和筛选期相比,受试者生活质量有明显提高(P均<0.01)。结论 理气活血滴丸治疗稳定性心绞痛有效可靠,安全性好,临床可继续推广应用。

【Abstract】 Objective To observe the efficacy and safety ofLiqihuoxuedripping pills in the treatment of chronic stable angina pectoris.Methods A total of 204 patients in the Affiliated Hospital of Qingdao University with chronic stable angina pectoris were enrolled, who tookLiqihuoxuedripping pills 10 capsules each time, 3 times a day for 4 weeks. Indicators such as effectiveness, safety and quality of life were regularly assessed.Results After 4 weeks′ treatment, the effective rate of the symptoms of angina pectoris were 91. 66%, the effective rate of electrocardiogram was 65. 69%, and the effective rate of nitroglycerin was 67. 15%. A total of 22 cases(10. 78%) had adverse events, and 4 cases(1. 96%) with possible drug-related adverse events. Compared with the screening period, the quality of life of the subjects was significantly improved after 4 weeks′ treatment(allP< 0. 01).Conclusion Liqihuoxuedripping pills is effective, reliable and safe in the treatment of stable angina pectoris. It can be applied clinically.

【基金】 贵州省重大科技专项资助(黔科合【2016】支撑2911);贵阳市科技计划项目(筑科合同【2017】29-1号)
  • 【文献出处】 临床合理用药杂志 ,Chinese Journal of Clinical Rational Drug Use , 编辑部邮箱 ,2022年22期
  • 【分类号】R259
  • 【下载频次】85
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