【摘要】 附子药用历史悠久,药效显著,素有"回阳救逆第一要药"之称。但其生品毒性大,须炮制入药以提高临床用药安全性。附子炮制方法众多,古有炮、烧、炙、炒、煨等,今有干热烘制、高压蒸制、微波炮制等,各法去毒存性效果不一。本文通过分析附子炮制典籍及现代研究,从古代附子炮制工艺、现代附子炮制工艺、炮制减毒原理以及各炮制方法比较等方面进行系统分析,在现有高压蒸制优化方法上,以多种双酯型生物碱和单酯型生物碱含量变化为指标,筛选出一种可供《中华人民共和国药典》收录的简便、规范的高压蒸制方案。更多还原

【Abstract】 Aconite has a long history of medicine and remarkable efficacy. It is known as "the first important medicine for reviving the yang for resuscitation". However,its raw products are highly toxic and must be processed into medicine to improve the safety of clinical medicine. There are many methods for processing aconite,such as roast,burn,processing,stir-frying and roasting processing have been widely used in ancient times. Today,new methods like dry-heat roasting,high-pressure steaming and microwave processing also have been developed. And the detoxification and function preserved of each method is different. This paper has analyzed the relevant classics and modern research on the processing of aconite,systematically compared from the aspects of ancient aconite processing technology,modern aconite processing technology,principle of processing and detoxification,comparison of processing methods. This paper has screened a simple and canonical high-pressure steaming plan through by the content changes of a variety of diester alkaloids and mo-noester alkaloids based on the existing high-pressure steaming method for the Chinese Pharmacopoeia.更多还原