【摘要】 目的 分析慢性阻塞性肺疾病（COPD）患者血清缺氧诱导因子（HIF-1α）与超敏C反应蛋白（hs-CRP）、肺功能的相关性，探讨HIF-1α与hs-CRP检测对COPD疾病进展的临床意义。方法 选取呼吸与危重症医学科就诊的COPD患者160例，依据肺功能检查分为轻度、中度、重度、极重度4组，每组40例。检测所有入组患者的血HIF-1α、hs-CRP浓度及肺功能，分析4组间HIF-1α、hs-CRP的差异及HIF-1α与hs-CRP、FEV₁的相关性。结果 HIF-1α、hs-CRP浓度在COPD患者中随疾病严重程度增加而逐渐升高，差异具有统计学意义（P<0.05）。4组患者中HIF-1α与hs-CRP均呈正相关关系、与FEV₁%均呈负相关关系（P<0.05）,且相关系数随疾病严重性增加而增高。结论 COPD缺氧与炎症互相影响、互为因果，促进了疾病进展。更多还原

【Abstract】 Objective To analyse the correlation between serum hypoxia-inducible factor（HIF）-1α,hypersensitive C-reactive protein（hs-CRP） and lung function in patients with chronic obstructive pulmonary disease（COPD）. To investigate the clinical significance of HIF-1α and hs-CRP on the progression of COPD.Methods 160 patients with COPD were selected and divided into four groups: mild, moderate, severe, and extremely severe based on the pulmonary function tests, with 40 cases in each group. The concentrations of HIF-1α and hs-CRP were detected and the pulmonary function of all enrolled patients were measured. The differences in HIF-1α and hs-CRP and the correlation between HIF-1α,hs-CRP,and FEV₁% among the four groups were analyzed.Results The concentrations of HIF-1α and hs-CRP gradually increased with the severity of the disease in COPD patients, and the difference was statistically significant（P<0.05）. HIF-1α was positively correlated with hs-CRP and negatively correlated with FEV₁% in all four groups（P<0.05）,and the correlation coefficients increased with the severity of the disease.Conclusion Hypoxia and inflammation of COPD affect each otherand promote the progression of the disease.更多还原