【摘要】 目的 探讨肿瘤浸润淋巴细胞(TILs)与食管胃结合部腺癌患者预后的相关性。方法 分析进行食管胃结合部腺癌根治术130例患者的临床病理资料，用染色法观察TILs。采用Kaplan-Meier绘制生存曲线，Cox单因素及多因素回归分析影响胃癌的预后因素。结果 食管胃结合部腺癌患者组织中高TILs比例组的总体生存率(92.16%)高于低TILs比例组的总体生存率(63.29%,P<0.05)。Cox多因素分析结果显示，肿瘤浸润深度、淋巴结转移、TILs比例、肿瘤直径为影响食管胃结合部腺癌患者预后的独立影响因素。结论 通过染色评估TILs比例可能成为食管胃结合部腺癌患者预后评估的重要指标，可用于指导临床工作。更多还原

【Abstract】 Objective To analyze the predictive value of tumor-infiltrating lymphocytes(TILs)in patients with esophagogastric junction adenocarcinoma.Methods The clinicopathological data of 130 patients who underwent radical resection of adenocarcinoma at the junction of esophagus and stomach were enrolled and analyzed.The tumor infiltrating lymphocytes were observed by hematoxylin and eosin(H-E)-staining.The survival curves of patients stratified by the Kaplan-Meier method.Multivariate Cox proportional hazards models were used to analyze the prognostic factors of gastric cancer.Results The overall survival in the high-TILs group(92.16%)were significantly higher than those in the low-TILs group(63.29%).The Cox multivariate analysis showed that degree of tumor invasion, lymph node metastasis, the proportion of TILs, and tumor diameter were independent factors affecting the prognosis of patients with esophagogastric junction adenocarcinoma.Conclusion Evaluating the proportion of TILs by using H-E staining may be an important prognostic indicator for patients with esophagogastric junction adenocarcinoma, which can be used to guide clinical work.更多还原