【摘要】 目的 探讨室间隔缺损患者介入封堵术前后促生长激素释放素(Ghrelin)、N末端B型利钠肽原(NT-proBNP)及心房钠尿肽(ANP)水平变化及其与心功能关系。方法 选取2018年1月至2020年1月住院治疗的107例行介入封堵术治疗的室间隔缺损患者作为研究对象。比较患者介入封堵术前与术后3个月时Ghrelin、NT-proBNP、ANP和心功能指标水平，患者介入封堵术后3个月Ghrelin、NT-proBNP、ANP水平与心功能指标水平的相关性。结果 室间隔缺损患者术后3个月的Ghrelin、NT-proBNP、ANP水平均低于术前，左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室收缩末期容量(LVESV)、左心室舒张末期容量(LVEDV)均小于术前(均P<0.05),但左室射血分数(LVEF)与术前差异无统计学意义(P>0.05)。Spearman相关性分析结果显示，室间隔缺损患者介入封堵术3个月后的Ghrelin、NT-proBNP、ANP水平与LVEDD、LVESD、LVESV、LVEDV均呈正相关(均P<0.05),与LVEF均无相关(均P>0.05)。结论 室间隔缺损患者介入封堵术3个月后Ghrelin、NT-proBNP、ANP水平均降低，心功能显著改善，且Ghrelin、NT-proBNP、ANP水平与心功能指标呈正相关。更多还原

【Abstract】 Objective To explore the changes in Ghrelin, N-terminal pro-B-type natriuretic peptide(NT-proBNP), and atrial natriuretic peptide(ANP) levels before and after the interventional occlusion in patients with ventricular septal defect and their correlations with the cardiac function. Methods A total of 107 patients with ventricular septal defect treated with interventional occlusion and hospitalized from January 2018 to January 2020 were selected as the research objects. The Ghrelin, NT-proBNP, ANP and the cardiac function indexes levels of patients were compared before and 3 months after the interventional occlusion. The correlations of the Ghrelin, NT-proBNP, and ANP levels with the cardiac function indexes levels of the patients 3 months after the interventional occlusion were analyzed. Results Compared with those before the operation, patients with ventricular septal defect had lower Ghrelin, NT-proBNP, and ANP levels and smaller left ventricular end-diastolic diameter(LVEDD), left ventricular end-systolic diameter(LVESD), left ventricular end-systolic volume(LVESV), and left ventricular end-diastolic volume(LVEDV) 3 months after the operation(all P<0.05), but the left ventricular ejection fraction(LVEF) showed no statistically significant difference(P>0.05). The results of Spearman rank correlation analysis showed that, in patients with ventricular septal defect 3 months after the operation, the Ghrelin, NT-proBNP, and ANP levels positively correlated with the LVEDD, LVESD, LVESV, and LVEDV(all P<0.05), but did not correlate with LVEF(all P>0.05). Conclusion Patients with ventricular septal defect had decreased Ghrelin, NT-proBNP, and ANP levels and improved cardiac function 3 months after the interventional occlusion, and the Ghrelin, NT-proBNP, and ANP levels positively correlated with the cardiac function.更多还原