【摘要】 良性前列腺增生(BPH)是老年男性中最常见的疾病之一。前列腺发育、生长过程受雄激素和生长因子的调控，其中前列腺上皮细胞和间质细胞分泌的生长因子起着关键作用。在成纤维细胞生长因子(FGF)家族和转化生长因子(TGF-β)家族中，FGF2和TGF-β1是前列腺中最具代表性的生长因子，它们参与前列腺细胞增殖、凋亡、迁移和分化等生物学过程的调控。因此，临床应用靶向FGF/TGF-β药物治疗BPH提供了理论基础。更多还原

【Abstract】 Benign prostatic hyperplasia(BPH) is a most common disorder in the elderly. The development and growth of the prostate are regulated by androgens and growth factors, and the latter are secreted by prostatic epithelial and mesenchymal cells and play a key role. As the family members of FGF and TGF-β, FGF2 and TGF-β1 are the most representative growth factors in the prostate, involved in the regulation of such biological processes as proliferation, apoptosis, migration and differentiation of prostate cells, which provides a theoretical basis for the clinical application of FGF-and TGF-β-targeted drugs in the treatment of BPH.更多还原