【摘要】 目的 探讨耐碳青霉烯类肺炎克雷伯菌感染的危险因素。方法 选取我院2019年2月～2020年3月收治的肺炎克雷伯菌感染患者133例作为观察对象，依据耐药性不同分为碳青霉烯类耐药肺炎克雷伯组(观察组)73例和碳青霉烯类敏感肺炎克雷伯组(对照组)60例。结果 观察组男52例(71.2%)、女21例(28.8)%,年龄>60岁35例(47.9%)。对照组男42例(70.0%)、女18例(30.0)%;年龄>60岁33例(55.0%)。两组患者主要分布在神经外科、肾内科、神经内科、呼吸内科、急诊内科、重症监护室(ICU);感染部位主要分布在下呼吸道、泌尿道、血液和皮肤软组织，两组比较差异无统计学意义(P>0.05)。观察组患者营养风险评分≥3分、1个月内应用碳青霉烯类药物、1个月内应用三代头孢/酶抑制剂、尿管留置、经外周静脉穿刺置入中心静脉导管(PICC)、应用抑酸剂≥5d、机械通气≥5d,鼻饲比例等高于对照组，1个月内应用碳青霉烯类药物、1个月内应用三代头孢/酶抑制剂、尿管留置是碳青霉烯类耐药肺炎克雷伯感染的危险因素，差异均有统计学意义(P<0.05)。结论 1个月内应用碳青霉烯类药物、1个月内应用三代头孢/酶抑制剂、尿管留置是碳青霉烯类耐药肺炎克雷伯感染的危险因素，应给予针对性措施以降低耐碳青霉烯类肺炎克雷伯菌感染的发生。更多还原

【Abstract】 Objective To approach risk factors of carbapenem-resistant Klebsiella pneumoniae infection.Methods The 133 cases carbapenem-resistant Klebsiella pneumoniae infection patients in our hospital were selected from 2019.2 to 2020.3 as object, which was to be divided into carbapenem resistant Klebsiella pneumoniae group 73 cases and carbapenem sensitive Klebsiella pneumoniae group 60 cases by different drug resistance.Results In the carbapenem resistant Klebsiella pneumoniae group, male were 52 cases(71.2%)、female were 21 cases(28.8%)、age>60 year 35 cases(47.9%),in the carbapenem sensitive Klebsiella pneumoniae group, male were 42 cases(70.0%)、female were 18 cases(30.0%)、age>60 year 33 cases(55.0%),Klebsiella pneumoniae infection of two group patients were distributed neurosurgery、nephrology、neurology、aspiration medicine、emergency Medicine、ICU,Klebsiella pneumoniae infection site of two group patients were lower respiratory tract、urinary tract、bloodstream and skin soft tissue, the differences were no statistical significance(P>0.05). Nutritional risk score≥3 score、carbapenem antibjotics within one month、 third-generation cephalosporins/enzyme inhibitors within one month、 indwelling catheter、PICC、acid inhibitor ≥5 d、nasal feeding proportion of carbapenem resistant Klebsiella pneumoniae group patients were higher than carbapenem sensitive Klebsiella pneumoniae group.Carbapenem antibjotics within one month、 third-generation cephalosporins/enzyme inhibitors within one month、 indwelling catheter are risk factor of carbapenem-resistant Klebsiella pneumoniae infection, the differences were statistically significant(P<0.05).Conclusion Carbapenem antibjotics within one month、 third-generation cephalosporins/enzyme inhibitors within one month、 indwelling catheter are risk factor of carbapenem-resistant Klebsiella pneumoniae infection, which should give targeted measures, decrease carbapenem-resistant Klebsiella pneumoniae.更多还原